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Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab

Head and Neck Cancer Clinical Trial

Official title:
Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab

Clinical Trial Summary

This is a non-randomized phase II study of targeted radiotherapy (RT) administered concurrently with panitumumab in patients with locally advanced squamous carcinoma of the head and neck.

Clinical Trial Description

This is a non-randomized phase II trial of targeted radiotherapy (RT) administered concurrently with panitumumab in patients with locally advanced squamous cell carcinoma of the head and neck. This protocol addresses patients with medical comorbidities that make them poor candidates for concurrent chemotherapy. Radiotherapy treatment will be directed at disease visible on diagnostic imaging modalities and the ipsilateral hemi-neck, sparing elective regions in the contralateral N0 hemi-neck with less than 20% chance of microscopic involvement. We explore the following hypothesis: Can acceptable locoregional disease control be obtained with less treatment-related morbidity by focusing RT on regions of gross disease, sparing regions with a low risk of harboring subclinical disease from elective RT? ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01312493
Study type Interventional
Source UNC Lineberger Comprehensive Cancer Center
Contact
Status Withdrawn
Phase Phase 2
Start date December 2011
Completion date December 2018
View Details
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