Head and Neck Cancer Clinical Trial
Official title:
Retrospective Analysis of ERCC1 Expression in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) Who Received Cisplatin or Cisplatin and Cetuximab
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is studying biomarkers in tissue samples from patients with
recurrent and/or metastatic squamous cell cancer of the head and neck previously treated
with cisplatin with or without cetuximab.
OBJECTIVES:
- To investigate the association between ERCC1 expression and clinical outcomes (response
rate, progression-free survival, and overall survival) in patients with recurrent
and/or metastatic squamous cell carcinoma of the head and neck who received cisplatin
with versus without cetuximab on clinical trial ECOG-E5397.
OUTLINE: Archived tumor tissue samples are analyzed for ERCC1 expression by IHC. ERCC1
levels (low or high) are assessed by an H-score and AQUA, a quantitative IHC analysis. Each
patient's ERCC1 level result is then compared with the patient's clinical outcome.
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