Head and Neck Cancer Clinical Trial
Official title:
Serum Biomarkers for Head and Neck Cancer
RATIONALE: Studying samples of blood, tissue, and saliva in the laboratory from patients
with cancer and from healthy volunteers may help doctors identify and learn more about
biomarkers related to cancer.
PURPOSE: This laboratory study is looking at biomarkers in patients with head and neck
cancer and in healthy volunteers.
OBJECTIVES:
- Correlate the differences in serum protein profiles with the differences in the number
of peptide matches in patients with squamous cell carcinoma of the head and neck and in
healthy volunteers.
- Correlate protein levels with the largest difference in peptide matches in sera in
these participants.
OUTLINE: This is a prospective study.
Participants undergo blood, tissue, and saliva collection for biological studies. Samples
are analyzed for albumin-bound and non-albumin-bound proteins or IgG via liquid
chromatography and tandem mass spectrometry (LC-MS-MS), ELISA, proteomic profiling, and
protein expression.
PROJECTED ACCRUAL: A total of 50 patients and 50 healthy volunteers will be accrued for this
study.
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