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Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

Head and Neck Cancer Clinical Trial

Official title:
A Phase 2 Study of De-Intensified Risk-Adapted Postoperative Radiation Therapy for Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma: the ADAPT Trial

Clinical Trial Summary

This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life.

Clinical Trial Description

This research study is being done to study if less intensive treatments can be used after surgery for head and neck cancers that are due to the human papilloma virus (HPV). In general, these cancers have better cure rates than other types of head and neck cancers. Therefore, the investigators are studying whether we can safely reduce the amount of treatment after surgery, such as surveillance (instead of using radiation) or less radiation or less chemotherapy, while maintaining good cure rates. The investigators hope that by reducing the intensity of treatment, this will lead to less side effects during and after cancer treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03875716
Study type Interventional
Source Dana-Farber Cancer Institute
Contact Danielle N. Margalit, MD, MPH
Phone 617-632-6817
Email dmargalit@lroc.harvard.edu
Status Recruiting
Phase N/A
Start date May 20, 2019
Completion date December 31, 2027
View Details
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