Effect of a Probiotic Water on Oral Health in Adults

Status Completed

Clinical Trial Summary

The purpose of this study is to evaluate the effects of consuming a probiotic on salivary, plaque, and tongue bacteria, as well as oral malodor (bad breath). Healthy volunteers will consume a probiotic powder, or a placebo powder, that is dissolved in water for 4 weeks.

Clinical Trial Description

The oral cavity houses one of the most diverse microbiota in the human body. There are nearly 800 unique oral bacterial species identified with more species expected to be added with further sampling and identification. As with microbiota of other sites in the body, a balanced oral microbiota is essential to maintaining the health of the human host. Streptococcus salivarius is a pioneer species that colonizes the human oral cavity from birth, and remains a predominant member of the commensal microbiota throughout life. The commensal microbiota provides protection against pathogenic species associated with conditions such as dental caries, periodontal disease, and oral malodor (halitosis). This randomized, double-blind, placebo-controlled study is conducted to investigate the effect of a Streptococcus salivarius DB-B5 strain on oral bacteria levels and halitosis. Doses of 2 billion and 10 billion colony forming units (CFU) per day are tested. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04473404
Study type	Interventional
Source	Dose Biosystems Inc.
Contact
Status	Completed
Phase	N/A
Start date	July 20, 2020
Completion date	August 26, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04279106` - Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath	N/A
Completed	`NCT04914208` - Effect of Wearing Face Masks on Salivary Parameters and Halitosis	N/A
Completed	`NCT05413382` - Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)	N/A
Completed	`NCT05524948` - A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis	N/A
Completed	`NCT02113137` - Oral Hygiene Procedures on Reduction of Oral Malodor	Phase 4
Completed	`NCT02689297` - Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds	Phase 4
Completed	`NCT01046812` - Halitosis Devised Questionnaire Evaluating a New Treatment	N/A
Withdrawn	`NCT02665780` - Assessing the Effect of Periodontal Debridement, Tongue Cleaning and Mouth Rinsing for the Treatment of Oral Malodour	N/A
Completed	`NCT01948349` - Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient	N/A
Recruiting	`NCT02007993` - Photodynamic Therapy in Adolescents Halitosis	N/A
Completed	`NCT01269957` - Halitosis and Mouth Breathing in Children	N/A
Completed	`NCT04632004` - Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health	N/A
Completed	`NCT04998617` - Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis	N/A
Completed	`NCT01139073` - A New Portable Monitor for Measuring Odorous Compounds in Oral, Exhaled and Nasal Air	N/A
Not yet recruiting	`NCT00875927` - Effects of Breezy Candy on Halitosis	Phase 1/Phase 2
Completed	`NCT03196648` - Randomized Trial of a Gum Health Formulation	N/A
Recruiting	`NCT03346460` - Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis	Phase 2
Completed	`NCT03468595` - Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis	N/A
Completed	`NCT02794766` - Inulin and S. Salivarius Reduce Halitosis	Phase 2
Completed	`NCT02628938` - Effect of Miswak and Miswak Extract on Oral Malodor	Phase 2