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Halitosis clinical trials

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NCT ID: NCT05647369 Completed - Clinical trials for Orthodontic Appliance Complication

Chios Mastic Mouthwash and Halitosis and Oral Hygiene in Orthodontic Patients

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

Halitosis is the third most common oral condition perceived by the patients as pathologic, after caries and periodontal diseases. Although it is difficult to estimate the prevalence of halitosis in the population due to the different assessment methods, the available descriptive epidemiologic studies estimate that 30-50% of the population experience oral malodor. Pathologic halitosis most commonly (85%) originates from the oral cavity and is a result of bacterial deposits that cover the tongue or are found in the inflamed oral mucosa, under poor-quality restorations, orthodontic mechanisms, carious lesions or mucosal ulcers. Odor usually results from the microbial degradation of organic substrates present in saliva. This interaction generates malodorous volatile sulfur compounds (VSCs), of which the three most common are: hydrogen sulfide (H2S), methyl-mercaptan (CH3SH) and dimethyl sulfide [(CH3)2S]. Orthodontic patients with fixed appliances are more prone to halitosis, due to the increased plaque accumulation and the increased amounts of available nutrients for the supragingival and subgingival microbes .

NCT ID: NCT05590897 Completed - Halitosis Clinical Trials

Assessment of Photodynamic Therapy With Annatto and Led for the Treatment of Halitosis in Mouth-Breathing Children

Start date: February 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Objective: To assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children. Methods: Fifty-two children six to twelve years of age with diagnoses of mouth breathing and halitosis (score of ≥ 3 on Breath Alert® portable breath meter) were randomly allocated to two groups (n = 26). Group 1: brushing, dental floss and aPDT applied to middle third of the dorsum of the tongue. Group 2: brushing, dental floss and tongue scraper. Breath meter results before, immediately after treatment as well as seven and 30 days after treatment were compared. The normality of the data will be determined using the Shapiro-Wilk test. Parametric data will be submitted to analysis of variance and nonparametric data will be compared using the Kruskal-Wallis test. The results of each treatment in the different periods of the study will be compared using the Wilcoxon test.

NCT ID: NCT05524948 Completed - Halitosis Clinical Trials

A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis

Start date: September 26, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the efficacy of an experimental dentifrice, containing 0.454 percent (%) stannous fluoride and 0.3% zinc chloride, to reduce oral malodor, compared to a marketed regular fluoride dentifrice after 3 weeks twice daily brushing in a population of clinically diagnosed gingivitis.

NCT ID: NCT05413382 Completed - Halitosis Clinical Trials

Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)

Start date: September 28, 2021
Phase: N/A
Study type: Interventional

This study is designed to evaluate the effect of an investigational lozenge with the enzyme polyphenol oxidase and green coffee extract in reducing and controlling intra-oral halitosis following immediate use and daily use of the lozenge over a one-week period.

NCT ID: NCT04998617 Completed - Halitosis Clinical Trials

Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis

Start date: May 24, 2022
Phase: N/A
Study type: Interventional

Purpose: To investigate the short-term clinical effect of curcumin-containing toothpaste on halitosis as compared to placebo and to assess potential shifts in the composition of dental biofilm associated with the use of curcumin-containing toothpaste Participants: This clinical study will 30 adult participants under prophylactic or periodontal maintenance protocol. Procedures (methods): Participants will be included and throughout the protocol will not allow the use any other oral hygiene products except standard manual toothbrush and study toothpaste (either test -curcumin-containing or placebo). Additionally participants will be instructed to odiferous foods such as onions, garlic and spices. At each of the three examination sessions, Plaque Index (six sites, O'Leary) and volatile sulphur compounds (VSC) will be measured.

NCT ID: NCT04914208 Completed - Halitosis Clinical Trials

Effect of Wearing Face Masks on Salivary Parameters and Halitosis

Start date: September 28, 2021
Phase: N/A
Study type: Interventional

During the current COVID-19 pandemic, the use of face masks is recommended / mandatory to prevent infection. Patients and students have reported to experience limitations in their oral health-related quality of life, especially with regard to the occurrence of dry mouth and halitosis, while wearing face masks. Scientific studies regarding the effects of face masks have so far focused exclusively on medical staff. Studies among the general population are not yet available, but are of interest as dry mouth is a risk factor for dental diseases (e.g., caries, erosion). Therefore, the present study aims at measuring the effect of wearing different face masks on salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity) and halitosis (volatile sulphur compounds).

NCT ID: NCT04779502 Completed - Halitosis Clinical Trials

The Efficacy of Oregano Essential Oil in Reducing Oral Halitosis

Start date: January 12, 2020
Phase: N/A
Study type: Interventional

the efficacy of commercially available oregano essential oil mouthwash in the reduction of oral halitosis was compared to chlorhexidine and distilled water and the results showed significant reduction of organoleptic tongue and floss scores and BANA test scores compared to placebo

NCT ID: NCT04632004 Completed - Halitosis Clinical Trials

Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health

Start date: November 20, 2020
Phase: N/A
Study type: Interventional

During the current COVID-19 pandemic, the use of face masks is recommended / mandatory to prevent infection. Patients and students have reported to experience limitations in their oral health-related quality of life, especially with regard to the occurrence of dry mouth and halitosis, while wearing face masks. Scientific studies regarding the effects of face masks have so far focused exclusively on medical staff. Studies among the general population are not yet available, but are of interest as dry mouth is a risk factor for dental diseases (e.g., caries, erosion). Therefore, the present study aims at performing a questionnaire survey regarding self-perceived dry mouth and halitosis and the use of face masks (type, wearing time).

NCT ID: NCT04589481 Completed - Bad Breath Clinical Trials

Effectiveness of Different Candies Against Bad Breath

HALIDROP
Start date: February 23, 2021
Phase: N/A
Study type: Interventional

This study is to analyze whether the candies can relieve or eliminate bad breath, both subjectively and objectively.

NCT ID: NCT04473404 Completed - Halitosis Clinical Trials

Effect of a Probiotic Water on Oral Health in Adults

Start date: July 20, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effects of consuming a probiotic on salivary, plaque, and tongue bacteria, as well as oral malodor (bad breath). Healthy volunteers will consume a probiotic powder, or a placebo powder, that is dissolved in water for 4 weeks.