Clinical Trials Logo

Clinical Trial Summary

Background. Hemophiliac arthropathy is the main long-term physical damage in patients with hemophilia, causing disability and functional limitations. Objective. Assessment of the efficacy of a prophylactic treatment with EHL products for improving the musculoskeletal health of adult patients with hemophilia. Study Design. Multicenter observational clinical study. Method. 40 patients with hemophilia A will be included in this study. Patients will be recruited from 5 centers located in various regions of Spain (Community of Madrid, Galicia, Community of Valenciana, Málaga and Vizcaya). The dependent variables will be: bleeding frequency (self-report of bleeding), changes in the dosage of factor VIII with EHL products (rFVIIIFc), pain (measured with the visual analog scale and a pressure Algometer), degree of kinesiophobia (Tampa Scale of Kinesiophobia), degree of adherence to treatment (Veritas-Pro scale), joint health (using the Hemophilia Joint Health Score), muscle strength (using a dynamometer) and functionality (using the 6-Minute Walking Test). Three evaluations will be carried out: baseline, at 6 months, and at the end of the study period, at 12 months. The evolution of quantitative variables shall be analyzed by parametric tests (t-student test) or non-parametric tests (Wilcoxon test). Pearson's correlation coefficient shall be used to obtain the correlation between the dependent and independent variables. By means of a linear regression analysis we will record the percentage influence of the clinical variables relative to the dependent variables measured in this study Expected results. The aim is to establish the effectiveness of the prophylactic treatment in the improvement of the state health, joint pain, muscle strength and functionality in patients with hemophilia.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03914209
Study type Observational
Source Investigación en Hemofilia y Fisioterapia
Contact Rubén Cuesta-Barriuso, PhD
Phone +34 607547274
Email ruben.cuestab@gmail.com
Status Recruiting
Phase
Start date June 2, 2020
Completion date October 15, 2021

See also
  Status Clinical Trial Phase
Completed NCT02229331 - Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait.
Completed NCT02870114 - National Survey of People With Haemophilia in Portugal N/A
Recruiting NCT02197611 - Development of a Specific Measure for Assessing Adherence in Adult Patients With Hemophilia. N/A
Unknown status NCT02582450 - Validation of a Specific Measure for Assessment of Compliance With Treatment in Patients With Hemophilia N/A
Completed NCT05138224 - Prevalence of Autistic Spectrum Disorder (ASD) in Children With Haemophilia
Recruiting NCT03287999 - Inter Individual Variability in Initiation Pathway Activation and Regulation and Phenotypic Heterogeneity in Patients With Haemophilia A and B
Completed NCT02825667 - Effectiveness of the Myofascial Therapy in the Hemophilic Arthropathy of Ankle N/A
Completed NCT03818529 - ATHN 8: Previously Untreated Patients (PUPs) Matter Study
Completed NCT05108480 - Self-myofascial Release With Foam Roller in Patients With Hemophilic Knee Arthropathy N/A
Completed NCT02781233 - A Progressive Resistance Training Program in Patients With Haemophilia N/A
Active, not recruiting NCT02581735 - Effectiveness of the uPatient Platform in Prophylactic Treatment in Hemophilia N/A
Active, not recruiting NCT02512211 - Validation of Questionnaires HAL and HEP N/A
Not yet recruiting NCT01623960 - Quality of Life in Adult Patients With Severe Haemophilia in Turkey N/A
Recruiting NCT02191436 - Adherence to Treatment in Hemophilia N/A
Completed NCT03264014 - Combining Registry Data in Haemophilia: TARGET H N/A
Recruiting NCT02198430 - Multidisciplinary Evaluation of Patients With Hemophilia N/A
Not yet recruiting NCT06046235 - Virtual Evaluations of Joint Health Using Wearable Sensors in Persons With Haemophilia (VESPA)
Completed NCT03529474 - Psychology and Physiotherapy Approach of Chronic Pain in Patients With Hemophilia N/A
Completed NCT05425888 - Functional and Proprioceptive Status in Patients With Hemophilic Ankle Arthropathy
Completed NCT04205188 - The Effects of Therapeutic Exercises on Kinesiophobia in Haemophilic Patients. N/A