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Haemodiafiltration clinical trials

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NCT ID: NCT04210154 Active, not recruiting - Haemodiafiltration Clinical Trials

Comparison of Pre- vs Post-dilution Haemodiafiltration in Children

Start date: February 1, 2021
Phase:
Study type: Observational

Cardiovascular morbidity and mortality are increased in children on conventional haemodialysis. Haemodiafiltration (HDF) is a newer type of dialysis which has two main types (post-dilution and predilution HDF). Post-dilution HDF is associated with better vascular health, blood pressure and growth in children. Furthermore, pre-dilution HDF is shown to remove a wider spectrum of uremic toxin compared to post-dilution HDF in adults. The investigators need more data to define the optimum dialysis modality for children.

NCT ID: NCT02063776 Active, not recruiting - Children Clinical Trials

Haemodiafiltration vs Conventional Haemodialysis in Children

3H
Start date: February 2014
Phase: N/A
Study type: Observational

Children on conventional haemodialysis (HD) die of heart disease. Also, they can be malnourished and short. Haemodiafiltration (HDF) is a newer type of dialysis that achieves better removal of toxins and excess fluid than HD. On HDF, adults have a longer survival and children show improved growth, but mechanisms are not understood. We will follow children in the UK and Europe to compare HDF and HD. We will monitor growth, heart and blood vessel scans, blood markers and quality of life. If the 3H (HDF-Hearts-Height) study shows reduced cardiovascular morbidity and better growth, HDF may be adopted as the preferred type of dialysis in children.