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Proof-of-concept Trial of Apraglutide in GVHD

GVHD Clinical Trial

Official title:
A Randomized, Single-blind Trial to Evaluate the Safety and Efficacy of Apraglutide in Subjects With Grade II to IV (MAGIC) Steroid Refractory Gastrointestinal (GI) Acute Graft Versus Host Disease on Best Available Therapy

Clinical Trial Summary

The aim of this trial is to assess safety and efficacy of apraglutide in subjects with steroid refractory gastrointestinal acute graft versus host disease (aGVHD).

Clinical Trial Description

This is an international, multicenter, randomized proof-of-concept trial to evaluate safety, tolerability, efficacy, durability of response, and clinical outcomes of apraglutide administration to subjects with steroid-refractory (SR) aGVHD of the lower GI tract being treated with systemic steroids (SS) and ruxolitinib (RUX). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05415410
Study type Interventional
Source VectivBio AG
Contact
Status Active, not recruiting
Phase Phase 2
Start date May 25, 2022
Completion date August 30, 2025
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