Food Assimilation Efficiency Clinical Trial
Official title:
Associations Between Gut Length, Gut Microbiota and Food Assimilation Efficiency of Healthy Individuals
The purpose of this observational study is to explore the correlation between human gut length and food absorption rates. This will include characterization of gut length, total food intake energy, fecal calories, urinary calories, body composition, food intake behavior, genetics and gut microbiota in the small intestine. Researchers expect to recruit up to 100 healthy volunteers.
The focus of this work was to characterize the relationships between gut length, gut microbiota and food assimilation rates in healthy individuals. The intestines will be scanned using Magnetic Resonance Imaging (MRI) to calculate the length of the intestines. For a clearer image, volunteers were required to drink 1/1.5 sachets He Shuang(Polyethylene Glycol Electrolyte powder) and were given an intramuscular injection of 10mg of Raceanisodamine Hydrochloride Injection to enhance the effect of the MRI. Volunteers were provided with experimental meals, and feces and urine were collected to calculate food absorption and metabolizable energy. At a later stage of the experiment, the gut microbiota was analyzed by macrogenomic and metabolomic analysis. The study combines metabolomics analysis techniques with imaging and physiological measurements, focusing on the correlation between gut length and food absorption rates. The researchers anticipate recruiting up to 100 healthy volunteers (body mass index ≥ 18.5) to explore the relationship between gut length and food absorption rate by measuring basic physiological indicators and metabolic parameters. ;