RWE-based Treatment Patterns and Outcomes in CIDP

Guillain-Barre Syndrome Clinical Trial

Official title: Characteristics, ImmunoglobulinTreatment Patterns, and Effectiveness in CIDP, Heredofamilial Amyloidosis, and Guillain-Barré Syndrome

Status Not yet recruiting

Clinical Trial Summary

To describe the demographics, clinical characteristics, treatment patterns and clinical outcomes of chronic inflammatory demyelinating polyneuropathy (CIDP), Guillain-Barre Syndrome (GBS), and heredofamilial amyloidosis (hATTR) adult patients at a single U.K. centre.

Clinical Trial Description

CIDP (chronic inflammatory demyelinating polyneuropathy) is an immune-mediated peripheral nerve disorder, that can be progressive or relapsing, with sensory or motor symptoms. It is typically diagnosed by a combination of progressive history, ruling out other neuropathic conditions, or by being refractive to immunoglobulin or corticosteroid treatment. Recently published guidelines introduced a pathway to diagnosis (Van den Burgh, 2021). Challenges with CIDP can result in misdiagnoses of hereditary amyloidosis (hATTR) and Guillain-Barré syndrome (GBS).

Studies in France, Italy, and Japan indicate that 15-53% of patients with hereditary amyloidosis (hATTR) have previously been diagnosed with CIDP (Russo 2020; Cortese 2017; Plante-Bordeneuve 2007; Koike 2011).

A study in the Netherlands highlighted the diagnostic challenges in diagnosis of acute onset CIDP versus (GBS) during the early acute phase onset (Ruts 2010). This diagnostic challenge may be driven by the lack of diagnostic tests or clinical features that can distinguish GBS acute onset CIDP (Van den Burgh, 2021).

A Hospital, Episode Statistics (HES) analysis of previous and subsequent primary diagnosis codes for CIDP patients highlighted hATTR and GBS, as well as unspecified [inflammatory] neuropathy codes, as three conditions with diagnostic challenges that might lead to reclassification of patients.

This current study is designed to describe the real-world demographics, clinical characteristics, and treatment pathways of patients diagnosed with CIDP, GBS and hATTR. In addition, this study will describe the real-world effectiveness and safety of immunoglobulin therapies in the treatment of patients with CIDP or GBS.

2.2. Objectives Primary Objective: To describe the baseline demographic and clinical characteristics CIDP, GBS and hATTR patients at a single U.K. centre, part of the Northern Care Alliance NHS Trust, in order to improve the understanding of the natural history of these neuropathic diseases.

Secondary Objectives:

• Describe the Ig treatment pathway and treatment-related outcomes in CIDP patients.

• Compare the Ig treatment pathway and treatment-related outcomes between typical and atypical CIDP

• Describe the characteristics of CIDP patients who are refractory to Ig treatment.

2.3. Study design This is a non-interventional, retrospective observational cohort study using the data collected during routine clinical appointments of patients with CIDP, hATTR, or GBS attending the Northern Care Alliance NHS Trust.

There will be no additional data collection or additional interventions carried out as part of this study.

All NHS patients have the opportunity to "opt out" as part of the national data opt-out is a service that allows patients to opt out of their confidential patient information being used for research and planning. Only data from patients who did not "opt out" will be used.

2.4. Population CIDP, GBS, and hATTR patients aged 18 years or over at diagnosis. 2.5. Variables

• CIDP, GBS and hATTR patient identifiers

• Demographics and clinical characteristics

• Treatments prescribed, with a focus on immunoglobulins and corticosteroids

• Clinical outcomes (grip strength test; 9-hole peg test; 50m walk test; Berg balance).

See section 4, table 2 for complete variable list. 2.6. Data sources Electronic medical records including inpatient, outpatient pharmacy datasets. The Ig Database dataset: NHS database of immunoglobulin therapy use, in which treatment data (date/dose) as well as outcome measures for patients who have received immunoglobulin therapy are recorded. This database is supported by MD-SAS.

3. Research question, objectives, and endpoints 3.1. Primary objectives To describe the demographics and clinical characteristics of CIDP, hATTR, and GBS patients in a single centre in the North West of England.

3.2. Primary endpoints

• Summary statistics and distributions of patient demographics reported for all patients diagnosed with CIDP, hATTR, or GBS, and by relevant subgroups, including:

• Age at diagnosis of CIDP, hATTR, or GBS

• Sex

• Ethnicity

• Comorbid diabetes

• CIDP type: typical, variant (distal, multifocal, focal, motor, sensory).

• Presenting symptoms at diagnosis

• History of [bilateral] carpel tunnel syndrome

• Genetic testing (for hATTR)

• Antibody testing IgM/IgG:

• Anti-neurofascin 155 (anti-NF155)

• Anti-contactin 1 (anti-CNTN1

• CIDP effectiveness measures at diagnosis or pre-Ig treatment initiation:

• Grip strength test (mean and range)

• 9-hole peg test (mean and range)

• 10m walk test (mean and range)

• Berg balance test (mean and range)

• Overall neuropathy limitations scale

• Medical research council muscle strength score

• Referrals to external centres

3.3. Secondary objectives

There are several secondary objectives:

• To describe the diagnostic pathways of CIDP, hATTR, and GBS patients in a single centre in the North West of England.

• To describe the effectiveness of intravenous and/or subcutaneous immunoglobulin in CIDP and GBS patients in a real-world setting in a single centre in the in the North West of England and nationally using the NHS Ig Database.

• To describe the treatment patterns of intravenous and/or subcutaneous immunoglobulin in CIDP and GBS patients in a real-world setting in a single centre in the in the North West of England and nationally using the NHS Ig Database.

3.4. Secondary endpoints

• For each confirmed CIDP, GBS and hATTR patient at the single centre in the North West:

list the previous neurological diagnosis codes (see Table 1) recorded in EHR, and frequency of previous codes (e.g. 1, 2, 3 or more.)

• For confirmed CIDP and GBS patients receiving immunoglobulin and present in the NHS Ig Database: record the changes in the following measurement outcomes taken prior to treatment start and at the end (~8 weeks later), stratified by patient demographics, clinical characteristics, and treatment:

• For confirmed CIDP and GBS patients receiving Ig and present in the NHS MD-SAS database, stratified by patient demographics, clinical characteristics, and treatment:

• Time from diagnosis to start of Ig treatment

• Proportion of patients receiving IV or SC at start of treatment

• Proportion of patients switching from IV to SC, or SC to IV

• Proportion of patients receiving Ig under homecare, stratified by IV or SC

• Median duration and range of each cycle of Ig treatment.

• Median time to Ig dose tapering.

• Percentage of Ig-treated patients who do not respond to treatment

• Percentage of Ig-treated patients who discontinue therapy, stratified by reason for discontinuation.

• Frequency of patients that achieve remission after each cycle of Ig treatment:

• Never

• A least once.

• 2-5 times.

• 5+ times.

• Median duration and range of remission.

• Relapse-free survival (where T0 is the last recorded Ig treatment): median and range.

• Frequency of relapse [set time duration: ever, in the last 12 months, 2 years, 5 years, 5+ years]:

• Never

• A least once.

• 2-5 times.

• 5+ times. ;

Related Conditions & MeSH terms

• Amyloidosis
• Amyloidosis, Familial
• Chronic Inflammatory Demyelinating Polyneuropathy
• Guillain-Barre Syndrome
• Polyneuropathies
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
• Syndrome

• NCT number: NCT05940922
• Study type: Observational
• Source: RwHealth
• Contact: Mike Hughes, Ph.D.
• Phone: 07462249069
• Email: mike.hughes@realworld.health
• Status: Not yet recruiting
• Start date: August 17, 2023
• Completion date: October 30, 2023