Differential Effects of rhGH vs. rhIGF-1 on Cardiovascular Risk Factors

Status Terminated

Clinical Trial Summary

The purpose of this study is to see if giving growth hormone or insulin-like growth factor-1 (IGF-1) to subjects with growth hormone deficiency effects cardiovascular risk factors differently.

Clinical Trial Description

Insulin-like growth factor-1 (IGF-1) in some circumstances acts as the mediator of the metabolic effects of growth hormone. However, there is some evidence to suggest that GH and IGF-1 act differently in some metabolic pathways. We will study the differences between GH and IGF-1 when provided as therapy for growth hormone deficiency in adults. Specifically we will be assessing if either medication impacts cardiovascular risk factors and if so do they impact risk factors differently. Ten adult males ages 18-65 who are growth hormone deficient on stable medications and with stable MRI findings (in the event of a known pituitary mass) will be recruited for the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00684957
Study type	Interventional
Source	Columbia University
Contact
Status	Terminated
Phase	N/A
Start date	January 2008
Completion date	October 2012

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