Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03807245
Other study ID # 2017-003871-27
Secondary ID
Status Completed
Phase Phase 1
First received
Last updated
Start date January 9, 2019
Est. completion date May 7, 2020

Study information

Verified date November 2020
Source Minervax ApS
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

A Phase I, randomised, single centre, double-blind, placebo-controlled, parallel group study to evaluate the safety, tolerability and immunogenicity of two doses of Group B Streptococcus vaccine.


Description:

There will be 4 arms in 2 cohorts of 30 subjects. Cohort 1 will receive two 0.5 mL injections, 4 weeks apart, each consisting of 25 μg of GBS-NN and 25 μg of GBS-NN2 (24 subjects) or placebo (6 subjects). Cohort 2 (30 subjects) will receive two 0.5 mL injections, 4 weeks apart, each consisting of 50 μg of GBS-NN and 50 μg of GBS-NN2 (24 subjects) or placebo (6 Subjects). All vaccines will be adsorbed to 500 μg Al3+ as Alhydrogel®. Safety will be assessed after all subjects have completed Visit 4 (Day 8) for Cohort 1, at which point the decision will be made as to whether proceeding with administration of the doses in cohort 2 is appropriate.


Recruitment information / eligibility

Status Completed
Enrollment 60
Est. completion date May 7, 2020
Est. primary completion date October 14, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: 1. Healthy female subjects aged 18 - 40 years. 2. Body mass index (BMI) =18 and =30 kg/m2. 3. Subjects weight =50kg and =100kg at screening. 4. Able to voluntarily provide written informed consent to participate in the study. 5. Subjects are pre-menopausal. 6. Females of childbearing potential must have a negative pregnancy test at screening (ß HCG) and prior to each dose. To prevent pregnancy female subjects of childbearing potential must take adequate contraceptive precautions for the entire duration of study participation (up to Day 85). Adequate and highly effective contraceptive precautions include: - Established use of oral, injected or implanted hormonal methods of contraception. - Placement of an intrauterine device (IUD) or intrauterine system (IUS). - Barrier methods of contraception: Condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository. - Male sterilisation (with the appropriate post-vasectomy documentation of the absence of sperm in the ejaculate). [For female subjects, the vasectomised male partner should be the sole partner for that subject]. - True abstinence, when this is in line with the preferred and usual lifestyle of the subject. [Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception]. • The chosen contraception method(s) must be followed from the first dose until at least Day 85 of the study. 7. Non-smokers for at least 3 months prior to first study vaccine administration. Exclusion Criteria: 1. Subjects who have received GBS-NN vaccine previously. 2. Subjects with history or presence of significant cardiovascular disease, pulmonary, hepatic, gallbladder or biliary tract, renal, haematological, gastrointestinal, endocrine, immunologic, dermatological, neurological, psychiatric, autoimmune disease or current infection. 3. Pregnant or lactating females. 4. Laboratory values at screening which are deemed by the investigator to be clinically significantly abnormal. 5. Positive drug screen for drugs of abuse or a positive alcohol urine test prior to first dosing unless there is a documented medical explanation for the positive result other than drugs of abuse (e.g., the subject has been prescribed opioids for pain). 6. Positive for human immunodeficiency virus (HIV), hepatitis B or hepatitis C. 7. Participation in a clinical drug study during the 90 days preceding the initial dose in this study. 8. Any significant illness during the 4 weeks preceding check-in for this study (Day 1). 9. Subjects with a history of allergic reactions after previous vaccination. 10. Subjects who have received any vaccine within 30 days of screening, or who are planning to receive a vaccine up to Day 85 of the study. 11. Subjects receiving immunosuppressive therapy in the 6 months prior to screening, taking any short-term medications including over-the-counter (OTC) preparations, within 7 days of the first dose. Chronic medications such as antihypertensives, bronchodilators, oral contraceptives or statins that do not affect the immune system, will be permitted and allowed to continue during the study at the discretion of the Investigator. Paracetamol will be permitted for the treatment of headache or other symptoms. Use of OTC vitamins and dietary supplements is allowed 12. Subjects with tattoos at the proposed site of vaccine administration. 13. Donation of blood or blood products within 90 days prior to vaccine administration or intending to donate blood or blood products within 90 days of the last visit. 14. Subjects who, in the opinion of the Investigator, are unsuitable for participation in the study.

Study Design


Related Conditions & MeSH terms


Intervention

Biological:
GBS-NN/NN2 with Alhydrogel® 25
GBS-NN/NN2 with Alhydrogel® vaccine will administered to subjects intramuscular 2 times with 4 weeks apart
Placebo GBS-NN/NN2 with Alhydrogel® 25
GBS-NN/NN2 with Alhydrogel® vaccine will administered to subjects intramuscular 2 times with 4 weeks apart
Placebo GBS-NN/NN2 with Alhydrogel® 50
GBS-NN/NN2 with Alhydrogel® vaccine will administered to subjects intramuscular 2 times with 4 weeks apart
GBS-NN/NN2 with Alhydrogel® 50
GBS-NN/NN2 with Alhydrogel® vaccine will administered to subjects intramuscular 2 times with 4 weeks apart

Locations

Country Name City State
United Kingdom Simbec Research Limited Merthyr Tydfil Wales

Sponsors (2)

Lead Sponsor Collaborator
Minervax ApS Simbec Research

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Number of Participants With Treatment Emergent Adverse Events Number of Participants with Treatment Emergent Adverse Events 85 days
Secondary Immunoglobulin(Ig)G Antibody Concentration Adjusted geometric mean concentration (GMC) Day 85
Secondary Fold Change in Antibody Concentration Geometric mean fold change in antibody concentration from Day 1 to Day 85 for each group. Day 1 to Day 85
Secondary Seroconversion Rate 4-fold increase in Immunoglobulin(Ig)G antibody concentration Day 85
Secondary Number of Participants With an Immune Response to First and Second Doses Number of participants with Immunoglobulin(Ig)G antibody concentration above thresholds Day 29 and Day 85
See also
  Status Clinical Trial Phase
Active, not recruiting NCT04653948 - Maternal, Neonatal and Infant Outcomes at Kawempe National Referral Hospital
Completed NCT04721912 - Group B Streptococcus Response After Probiotic Exposure Phase 3
Active, not recruiting NCT04549220 - Serosurveillance Study of Maternally Derived Anti-GBS Antibody
Recruiting NCT04732026 - Serocorrelate of Protection Against GBS (PREPARE WP3)