Evaluation of 41 Cases of Pediatric Granuloma Annulare

Granuloma Annulare Clinical Trial

Official title:

Clinical and Histopathological Evaluation of 41 Cases of Pediatric Granuloma Annulare

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05472636
• Other study ID #: 97
• Status: Completed
• Start date: March 11, 2022
• Est. completion date: June 1, 2022

Study information

• Verified date: July 2022
• Source: Istanbul Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study.

MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.

Description:

Granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. Diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. While there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. Therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study.

This study was performed retrospectively in a single-center tertiary dermatology hospital. Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Cases with uncertain diagnosis were not included in the study. Cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. Demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: June 1, 2022
• Est. primary completion date: May 11, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• Being under 18 years old

• Having granuloma annulare

• Applying to the Istanbul Training and Research Hospital, Dermatology Outpatient Clinic between 2008-2021

• Consenting to participate in the study

Exclusion Criteria:

-Being over 18 years old

Related Conditions & MeSH terms

• Granuloma
• Granuloma Annulare

Locations

Country	Name	City	State
Turkey	Istanbul Training and Research Hospital	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluation of the genders of the pediatric patients with granuloma annulare	male, female	day 0
Primary	Evaluation of the ages of the pediatric patients with granuloma annulare	age (year)	day 0
Primary	Evaluation of the concomitant diseases of the pediatric patients with granuloma annulare	the concomitant diseases of the participants	day 0
Primary	Evaluation of the lesion localization of the pediatric patients with granuloma annulare	head and neck, upper extremity, lower extremity, trunk	day 0
Primary	Evaluation of the lesion duration of the pediatric patients with granuloma annulare	the time interval in between appearance of the lesion and diagnosis (month)	day 0
Primary	Evaluation of the lesion type of the pediatric patients with granuloma annulare	papule, pustule, plaque, nodule	day 0
Primary	Evaluation of the mean size of the lesion	diameter (cm)	day 0
Primary	Evaluation of the clinical involvement	localized, generalized	day 0
Primary	Histopathological evaluation of the infiltration type of the pediatric patients with granuloma annulare	neutrophilic, lymphocytic, lymphohistiocytic, eosinophil, mixed infiltrations	day 0
Primary	Histopathological evaluation of the infiltration pattern of the pediatric patients with granuloma annulare	Interstitial, palisadic	day 0
Primary	Evaluation of epidermal findings	regular/irregular, hyperkeratosis, acanthosis	day 0
Primary	Evaluation of depth of infiltrate	superficial, medium, deep	day 0