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Granuloma Annulare clinical trials

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NCT ID: NCT05650736 Active, not recruiting - Granuloma Annulare Clinical Trials

Janus Kinase Inhibition in Granuloma Annulare

Start date: October 27, 2023
Phase: Phase 2
Study type: Interventional

The primary objective is to determine if JAK1 specific inhibition is effective in treating granuloma annulare (GA), a problematic inflammatory skin disease without an FDA approved treatment. The primary outcome will be the percentage change in the body surface area (BSA) involvement by GA after 6 months of treatment with abrocitinib 200 mg daily in 10 patients with moderate to severe GA affecting at least 5% body surface area (BSA).

NCT ID: NCT05580042 Recruiting - Granuloma Annulare Clinical Trials

Study to Evaluate the Safety and Tolerability of AC-1101 Topical Gel in Patients With Granuloma Annulare

Start date: October 3, 2022
Phase: Phase 1
Study type: Interventional

Study AC-1101-GA-001 is an early phase open-label study with a 4-week treatment and 2-week follow-up period (without treatment) to assess the safety, tolerability, and efficacy of AC-1101 gel in patients with Granuloma Annulare.

NCT ID: NCT05472636 Completed - Granuloma Annulare Clinical Trials

Evaluation of 41 Cases of Pediatric Granuloma Annulare

Start date: March 11, 2022
Phase:
Study type: Observational

INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study. MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.

NCT ID: NCT03910543 Completed - Granuloma Annulare Clinical Trials

Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare

Start date: April 11, 2019
Phase: Phase 1
Study type: Interventional

To investigate the ability of tofacitinib, a Janus kinase (JAK) inhibitor, to treat patients with cutaneous sarcoidosis and granuloma annulare during 6 months of therapy.

NCT ID: NCT03630198 Completed - Plaque Psoriasis Clinical Trials

Pain Outcomes Following Intralesional Corticosteroid Injections

Start date: October 1, 2018
Phase: Phase 4
Study type: Interventional

Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment. Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure. The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.

NCT ID: NCT00720980 Completed - Granuloma Annulare Clinical Trials

Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Start date: May 2008
Phase:
Study type: Observational

Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.

NCT ID: NCT00476697 Terminated - Scleroderma Clinical Trials

UVA1 Light for Scleroderma and Similar Conditions

Start date: January 1997
Phase: N/A
Study type: Interventional

The purpose of this investigation is to evaluate the effectiveness of high-dose UVA1 irradiation in the treatment of fibrosing conditions of the skin, e.g., keloid (a thick scar from growth of fibrous tissue), scleroderma (deposits of fibrous tissue in the skin) and acne keloidalis nuchae (keloids on the back of the neck or hairline) old burn scars, granuloma annulare or other similar skin conditions. This UVA1 dosing schedule has been used successfully in Germany for various skin diseases, such as the above mentioned scleroderma.

NCT ID: NCT00129428 Completed - Keloid Clinical Trials

Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix

Start date: August 2002
Phase: Phase 1/Phase 2
Study type: Interventional

This research study will evaluate the effectiveness of high dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis nuchae, old burn scars, granuloma annulare or related conditions.