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Clinical Trial Summary

Allogeneic hematopoietic cell transplantation (HCT) is one of the only curative intent therapies available for hematologic malignancies. HLA-matched sibling donors have historically offered the best clinical results but are unavailable for the majority of patients, while most patients do have readily available haploidentical donors. One of the risks of a haploidentical HCT is graft vs. host disease (GVHD), but it is difficult to reduce the incidence of GVHD without compromising the graft vs. leukemia (GVL) effect. The hypothesis of this study is that JAK inhibition with haploidentical HCT may mitigate GVHD and cytokine release syndrome while retaining the GVL effect and improving engraftment.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06008808
Study type Interventional
Source Washington University School of Medicine
Contact Ramzi Abboud, M.D.
Phone 314-454-8304
Email rabboud@wustl.edu
Status Recruiting
Phase Phase 1
Start date May 7, 2024
Completion date December 11, 2026

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