The Influence of Cholecystectomy on Secretion of Incretin Hormones

Status Completed

Clinical Trial Summary

The effect of cholecystectomy on postprandial plasma GLP-1 responses (primary endpoint) and glucose metabolism will be evaluated in 30 patients planned to undergo elective laparoscopic cholecystectomy.

Clinical Trial Description

This is an observational, parallel-group study in 30 patients with gallstone disease and 10 healthy control subjects. In patients undergoing cholecystectomy a 4h-meal test (liquid mixed meal) will be conducted at baseline (1-2 weeks before surgery) and again within 4 weeks after the cholecystectomy. Healthy subjects will be submitted to a single 4h-meal test. Secondary endpoints include changes in plasma glucose, insulin, glucagon, GIP, PYY, gastrin, CCK, fibroblast growth factor 19 (FGF-19) and bile acids. Furthermore, secondary endpoints include changes in gastric emptying (evaluated by the paracetamol method). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03305783
Study type	Observational
Source	University Hospital, Gentofte, Copenhagen
Contact
Status	Completed
Phase
Start date	November 1, 2017
Completion date	April 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05081037` - Integrated Hyperglycaemia Incentivised Postnatal Surveillance Study (I-HIPS)	N/A
Recruiting	`NCT05544266` - Rare and Atypical Diabetes Network
Recruiting	`NCT04039763` - RT-CGM in Young Adults at Risk of DKA	N/A
Active, not recruiting	`NCT05505994` - The Efficacy and Safety of DWP16001 in Combination With Metformin in T2DM Patients Inadequately Controlled on Metformin	Phase 3
Completed	`NCT03623113` - The Dietary Education Trial in Carbohydrate Counting (DIET-CARB Study in Type 1 Diabetes	N/A
Completed	`NCT03623139` - Effects of Basic Carbohydrate Counting Versus Standard Outpatient Nutritional Education in Type 2 Diabetes	N/A
Completed	`NCT03359629` - Spectrophon LTD Glucometry Monitor Accuracy
Recruiting	`NCT03682640` - Azithromycin Insulin Diet Intervention Trial in Type 1 Diabetes	Phase 2
Completed	`NCT02697305` - Incretin Effects of Branched Chain Amino Acids	N/A
Completed	`NCT01737164` - Effect of Age on Glucose and Lipid Metabolism	N/A
Terminated	`NCT00935766` - Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries	Phase 3
Recruiting	`NCT03613688` - Effects of Deepure(Pu-erh Tea Extract) on Glycemic Control	N/A
Completed	`NCT04098549` - The Effect of Rapid and Slow Glucose Fall on the Subsequent Glucose Production in People With Type 1 Diabetes	N/A
Terminated	`NCT04031404` - Glucose and Non-Invasive Brain Stimulation	N/A
Active, not recruiting	`NCT03577964` - Development of Pneumonia Due to Alveolar Glucose Levels in Systemic Hyperglycemia
Active, not recruiting	`NCT03232008` - Canderel:Effects on Blood Glucose Concentration and Appetite Scores	N/A
Completed	`NCT04042142` - Glucagon Resistance in Patients With NAFLD	N/A
Active, not recruiting	`NCT05607745` - Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study	N/A
Completed	`NCT04004273` - Diabetes, Exercise and Liver Fat (DELIVER)	N/A
Completed	`NCT04082923` - Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery	N/A