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Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids

Glucose Intolerance Clinical Trial

Official title:
Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids

Clinical Trial Summary

This study evaluates the effect of acute administration of oral prednisone in white blood cells counts and glucose tolerance and the relationship of these measures with changes in gene expression in healthy volunteers. White blood cells counts, glucose tolerance and gene expression will be study before and after prednisone administration.

Clinical Trial Description

Prednisone is a potent anti-inflammatory drug that has large variability in its response. The large inter individual variability in the response to prednisone has a genetic component, but the genetic determinants of this variability remain unknown. We propose to use two relevant phenotypes, changes in white blood cell counts and changes in glucose tolerance induced by in vivo administration of prednisone, to characterize gene expression patterns and identify variants that are involved in the in vivo response to prednisone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03023891
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase Phase 1
Start date February 15, 2017
Completion date December 31, 2019
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