Glucose and Lipid Metabolism Clinical Trial
Official title:
Effects of Aleurone-enriched Products on Fasting and Postprandial Glycemic Homeostasis and Lipid Metabolism in High Cardiovascular Risk Subjects
Very few studies have evaluated the effect of aleurone-enriched grains on cardiovascular
risk factors. Price et al.(2010) have shown that 4-week supplementation of aleurone-enriched
products (27 g/day of aleurone) increased betaine concentration in plasma whereas reduced
homocysteine and LDL-cholesterol levels. Interestingly, aleurone had no effect on total
antioxidant status or endothelial function, whereas an improvement of C-reactive protein was
observed (Price RK et al, 2012). It is not known whether consumption of more than 27g/day of
aleurone-enriched products with higher ferulic acid biodisponibility and longer time of
treatment could influence these parameters in individuals with metabolic syndrome.
Noteworthy, no studies have investigated the effect of aleurone-enriched products on fasting
and postprandial glycemic homeostasis and lipid metabolism. In addition, mechanisms by which
aleurone may act in vivo are still unknown.
The aim of this study is to investigate whether 8 weeks supplementation with
aleurone-enriched products may influence glucose and lipid metabolism, incretin hormones
levels, satiety, inflammation, oxidative stress and endothelial function in overweight/obese
subjects with high cardiovascular risk.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment