Glioma Clinical Trial - A Study Utilizing Escitalopram in Glioma Patients

Status Recruiting

Clinical Trial Summary

This pilot study will include grade IV glioma patients treated with SSRIs during approximately a 17 week study period. Changes in cognition and evaluation of psychosocial factors from baseline to after 17 weeks of treatment with SSRI study drug will be calculated.

Clinical Trial Description

As many as 85% of glioma patients experience cognitive impairment. This is not only from direct tumor involvement, but also worsens with therapy such as cranial radiation and chemotherapy, which further degrade neuronal function. Commonly, impairments in visuospatial skills and executive function are seen. There is evidence that serotonin selective reuptake inhibitors (SSRIs) such as escitalopram improve modulation and function of resting state networks, contribute to neuroplastic changes in brain regions subserving these abilities, and provide general functional support to neuronal cells. In addition to either improving cognition or preventing cognitive decline, treatment with an SSRI may also improve outcomes critical to overall survival in this vulnerable population, including functional independence, psychosocial stability, and quality of life. We hypothesize that following treatment with escitalopram patients will experience improved cognitive and mood function over time. We will also correlate changes in mood structural MRI and electrophysiological correlates of visual pathway function. The addition of escitalopram has the potential to enhance cognitive function and hence functional independence thereby improving quality of life in these patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03728673
Study type	Interventional
Source	University of Nebraska
Contact	Michaela K Savine, RN
Phone	402-836-9488
Email	misavine@unmc.edu
Status	Recruiting
Phase	Phase 2
Start date	March 6, 2019
Completion date	August 2025

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