Glioma Clinical Trial
Official title:
Monitoring and Analysis of Gene Expression, Immunological Status and Metabolome in Peripheral Blood Mononuclear Cells and Their Specific Subpopulations (CD4+ T Cells and CD56+ NK Cells) in Surgically Treated Glioma Patients
Study on glioma patients treated with brain surgery is focusing on the analysis of their
transcriptome expression profile measured in two immune cell populations, CD4+ T cells and
CD56+ NK cells. The results of analysis will be compared to the reference data of healthy
population. Furthermore, the metabolomic and immunological status will also be monitored and
compared to healthy group reference data, before and after the surgery*. With comparative
crossomics analysis the investigators intend to possibly identify new diagnostic and
prognostic biological markers for the relapse of the disease. The results are expected to
convey a deeper insight into pathophysiology of the glioma as well as into the mechanisms of
the current surgical therapy.
* The healthy reference data have been published in collaborative efforts of BTC, UMC and
NIB (Gruden et al. 2012).
n/a
Observational Model: Cohort, Time Perspective: Prospective
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