Glioma Clinical Trial
Official title:
Weekly Vinblastine for Chemotherapy Naive Children With Progressive Low Grade Glioma (PLGGs)
The overall objective of this study is to determine the efficacy of weekly Vinblastine in chemotherapy naïve patients with progressive or incompletely resected paediatric low grade glioma, to generate estimates of the response rate, progression-free survival, toxicity and quality of daily living among the population treated and determine biologic factors which will enable us to predict tumour behaviour.
Unresectable low grade glioma (LGG) of childhood increasingly appears as a chronic condition
for which multiple treatments may be required. While several studies have shown evidence of
short term tumour control with chemotherapy, the progression-free survival at 5 years is
unsatisfactory. In addition, several regimens currently used for this condition are
associated with significant risks of side effect and long term toxicity.
We have piloted in a single arm study the feasibility and efficacy of Vinblastine for
children with recurrent and refractory low grade glioma, who have failed at least one line of
treatment (chemotherapy and/or irradiation). Preliminary results show promising activity with
minimal toxicity.
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