A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma

Glioma Clinical Trial

Official title:

A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00389090
• Other study ID #: O6BG 202
• Status: Terminated
• Phase: Phase 2
• First received: October 16, 2006
• Last updated: February 7, 2012
• Start date: October 2006
• Est. completion date: February 2009

Study information

• Verified date: February 2012
• Source: Keryx / AOI Pharmaceuticals, Inc.
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

This is an open-label, multicenter, phase II trial, assessing the antitumor activity, and safety of temozolomide in combination with O6-BG in patients with temozolomide-resistant anaplastic glioma.

Description:

This open-label, multicenter, phase II trial will assess the antitumor activity and safety of temozolomide in combination with O6-BG in patients with temozolomide-resistant anaplastic glioma.

Forty-one to 104 evaluable patients with temozolomide-resistant anaplastic glioma will be enrolled in this study. Total accrual on this study will not exceed 116 patients. The patients will receive daily temozolomide on 5 consecutive days (days 1-5) along with bolus infusions of O6-BG on days 1, 3, and 5 and a continuous infusion of O6-BG beginning immediately after the first bolus infusion and continuing until immediately prior to the last bolus injection. Patients will be evaluated for AEs during the course of therapy. Patients may receive treatment at the same dose level until appearance of significant treatment-related toxicities, disease progression or withdrawal of consent.

Tumor response will be evaluated at the end of cycle 1, cycle 2 and then every two cycles for the duration of therapy, using physical and neurological examinations and diagnostic imaging.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 32
• Est. completion date: February 2009
• Est. primary completion date: June 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Patients with histologically documented anaplastic glioma (anaplastic astrocytoma, anaplastic oligodendroglioma or mixed anaplastic oligoastrocytoma).

2. Temozolomide-resistant defined as patients who have progressed while receiving or within 8 weeks of completing the last dose of temozolomide.

3. Disease progression >= 12 weeks after the completion of any radiotherapy.

4. If patient received chemotherapy or an investigational agent as part of their prior therapy, the patient must recover from all toxicities (<= Grade 1) prior to enrollment on this protocol.

5. Bi-dimensionally measurable disease on contrast-enhanced magnetic resonance imaging study (MRI) performed within two weeks of study drug administration.

6. If patient received intratumoral chemotherapy or immunotherapy as part of their prior therapy then histological confirmation of recurrence is mandated.

7. KPS >= 70%.

8. The following laboratory results:

• Absolute neutrophil count >= 1500 cells/microliter

• Platelet count >= 100,000 cells/microliter

• SGOT <= 2.5 x ULN

• Serum creatinine <= 1.5 x ULN

9. Signed informed consent approved by Institutional Review Board.

10. If sexually active, patients will take contraceptive measures for the duration of the treatment.

11. For patients on corticosteroids, they must have been on a stable dose 1 week prior to baseline MRI and the dose should not be escalated over entry dose level, if clinically possible.

Exclusion Criteria:

1. Pregnant or breast feeding women.

2. Prior treatment with O6-BG plus temozolomide in combination.

3. Active infection requiring intravenous antibiotics.

4. Known diagnosis of Human Immunodeficiency Virus (HIV) infection (HIV testing is not mandatory).

5. Patients with a history of another primary malignancy that is currently clinically significant or currently requires active intervention.

6. Patients unwilling or unable to comply with the protocol.

7. Patients who have received stereotactic radiosurgery or brachytherapy as part of their prior therapy.

8. Comedication that may interfere with study results; eg. immunosuppressive agents other than corticosteroids.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Astrocytoma
• Glioma
• Oligoastrocytoma
• Oligodendroglioma

Intervention

Drug:
• Temozolomide and O6-Benzylguanine
O6BG + Temozolomide

Locations

Country	Name	City	State
United States	AOI Pharmaceuticals Investigative Site	Chicago	Illinois
United States	AOI Pharmaceuticals Investigative Site	Dallas	Texas
United States	AOI Pharmaceuticals Investigative Site	Durham	North Carolina
United States	AOI Pharmaceuticals Investigative Site	Evanston	Illinois
United States	AOI Pharmaceuticals Investigative Site	Greenville	South Carolina
United States	AOI Pharmaceuticals Investigative Site	Houston	Texas
United States	AOI Pharmaceuticals Investigative Site	Lexington	Kentucky
United States	AOI Pharmaceuticals Investigative Site	Los Angeles	California
United States	AOI Pharmaceuticals Investigative Site	Louisville	Kentucky
United States	AOI Pharmaceuticals Investigative Site	Minneapolis	Minnesota
United States	AOI Pharmaceuticals Investigative Site	Orlando	Florida
United States	AOI Pharmaceuticals Investigative Site	Salt Lake City	Utah

Sponsors (1)

Lead Sponsor	Collaborator
Keryx / AOI Pharmaceuticals, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	best objective response rate		Month 1, 2 and every 2 months thereafter.	No
Secondary	Safety Assessment		Month 1, 2 and every 2 months thereafter	Yes
Secondary	progression-free survival		every 6 months	No
Secondary	overall survival		every 6 months	No