Glioma Clinical Trial
Official title:
Cognitive Rehabilitation of Glioma Patients: a Prospective, Randomized Study
Verified date | July 2007 |
Source | UMC Utrecht |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to determine whether cognitive rehabilitation is effective in patients with gliomas (brain tumour), by comparing direct and follow-up neuropsychological functioning and quality of life of the experimental group to the control group.
Status | Unknown status |
Enrollment | 140 |
Est. completion date | September 2007 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - adult patients with a histologically proven low-grade glioma or presumed (i.e., suspected) low-grade glioma based on both clinical and MR imaging feature, and - adult patients with an anaplastic glioma (anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligo-astrocytoma) under age 50 and with good performance status (KPS > 70); - who are clinically stable for a minimum of 6 months prior to study entry (as determined by recent CT or MRI imaging) and no anti-tumor treatment during that period of time (i.e., surgery, radiotherapy, chemotherapy, corticosteroids); - who report at least one symptom of impaired cognitive functioning based on a standardized self-report questionnaire, administered by researcher; - and who meet criteria for neuropsychological impairment based on objective test results (assessed by researcher). Exclusion Criteria: - lack of basic proficiency in Dutch; - IQ below 85; - severe reading problems; - an additional (history of) neurological or psychiatric disorder; - participating in a concurrent study in which neuropsychological testing and/or health-related quality of life assessments are involved |
Country | Name | City | State |
---|---|---|---|
Netherlands | Netherlands Cancer Institute | Amsterdam | |
Netherlands | VU Medical Center | Amsterdam | |
Netherlands | Medical Center Haaglanden | Den Haag | |
Netherlands | UMC Groningen | Groningen | |
Netherlands | AZ Maastricht | Maastricht | |
Netherlands | UMC St Radboud | Nijmegen | |
Netherlands | Erasmus Medical Center | Rotterdam | |
Netherlands | Sint Elisabeth Hospital | Tilburg | |
Netherlands | University Medical Center Utrecht | Utrecht |
Lead Sponsor | Collaborator |
---|---|
UMC Utrecht | Dutch Cancer Society |
Netherlands,
Klein M, Heimans JJ, Aaronson NK, van der Ploeg HM, Grit J, Muller M, Postma TJ, Mooij JJ, Boerman RH, Beute GN, Ossenkoppele GJ, van Imhoff GW, Dekker AW, Jolles J, Slotman BJ, Struikmans H, Taphoorn MJ. Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study. Lancet. 2002 Nov 2;360(9343):1361-8. Erratum in: Lancet. 2011 May 14;377(9778):1654. — View Citation
Taphoorn MJ, Klein M. Cognitive deficits in adult patients with brain tumours. Lancet Neurol. 2004 Mar;3(3):159-68. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | neuropsychological measures of attention (test scores) | baseline, immediately after 6 weeks and at 6-month follow-up | ||
Secondary | neuropsychological measures of memory and executive functioning (test scores) | baseline, immediately after 6 weeks and at 6-month follow-up | ||
Secondary | subjective neuropsychological functioning (questionnaires) | baseline, immediately after 6 weeks and at 6-month follow-up | ||
Secondary | quality of life (questionnaires) | baseline, immediately after 6 weeks and at 6-month follow-up |
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