Glioma Clinical Trial
Official title:
Angiogenic Profile and Non-invasive Imaging May Predict Tumor Progression of High Risk Group Low Grade Glioma (LGG)
The low grade glioma (LGG) is a type of brain tumor which is generally more common in
younger age group patients. Most patients with LGG undergo surgery which is mostly
incomplete due to concern about loss of function. This is an incurable disease. More than
half of these patients progress to a higher grade with a worse outcome within five years of
their diagnosis and only one-third survive for up to ten years. Post-operative radiation
treatment improves local control without survival advantage. Efforts are being made without
great success to select the patients with a higher risk of progression based on physical
characteristics and histological features.
Tumor vascularity is thought to be the key element in tumor progression. Tremendous progress
has been made in functional imaging by using magnetic resonance imaging (MRI) 3-Tesla (3T)
and in biotechnology which can be used to investigate angiogenic gene profiles in order to
identify gene signature for these tumors. In this study the investigators are proposing that
patients of LGG with a higher risk of tumor progression may be selected by functional
imaging and angiogenic profiles. These higher risk patients may be candidates for
post-operative radiation in the future with a potential survival benefit.
Summary: Comprehensive analysis of the angiogenesis-related gene expression profiles and tumor perfusion of patients with LGG will provide a novel understanding of subgroup (low and high-risk) of LGG. Thus, this study will allow identifying clinically relevant factors predictive for tumor progression and to select patients in high-risk group for adjuvant radiation therapy. ;
Observational Model: Case-Only, Time Perspective: Prospective
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