Glaucoma Clinical Trial
Official title:
Anterior Segment Changes Before and After Uneventful Combined Phaco-Trabeculectomy by Using Optical Coherence Tomography (OCT)
1. Develop a measurement protocol by OCT imaging and characterization of the anterior
chamber change in glaucoma patients before and after surgery.
2. Show the effect of combined surgery in control of intra ocular pressure.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | March 1, 2020 |
Est. primary completion date | September 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Men and women aged over 18 years - Diagnosed primary open angle glaucoma - Visual field defects and optic nerve head appearance characteristic for glaucoma - Angle closure predisposition as evidenced from gonioscopy. - Neovascularization in the anterior chamber angle - pseudo-exfoliation glaucoma as evidenced from slit lamp examination - No cataract surgery. - No glaucoma surgery - No degenerative changes in the retina in funduscopy after mydriasis Exclusion Criteria: - -previous glaucoma surgery - Previous cataract surgery - Presence of any abnormalities preventing reliable measurements - Ocular inflammation and ocular disease interfering with the study - Corneal, macula, and other corneal disease. - No fixation Funds lesions such as diabetic retinopathy or retinal detachment. |
Country | Name | City | State |
---|---|---|---|
Egypt | Assiut university | Assiut |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Egypt,
Hong CJ, Trope GE. Glaucoma. CMAJ. 2015 Sep 8;187(12):E398-9. doi: 10.1503/cmaj.140401. Epub 2014 Nov 24. — View Citation
Maslin JS, Barkana Y, Dorairaj SK. Anterior segment imaging in glaucoma: An updated review. Indian J Ophthalmol. 2015 Aug;63(8):630-40. doi: 10.4103/0301-4738.169787. Review. — View Citation
Salim S. The role of anterior segment optical coherence tomography in glaucoma. J Ophthalmol. 2012;2012:476801. doi: 10.1155/2012/476801. Epub 2012 Aug 1. — View Citation
Sharma R, Sharma A, Arora T, Sharma S, Sobti A, Jha B, Chaturvedi N, Dada T. Application of anterior segment optical coherence tomography in glaucoma. Surv Ophthalmol. 2014 May-Jun;59(3):311-27. doi: 10.1016/j.survophthal.2013.06.005. Epub 2013 Oct 15. Re — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Biometric parameters measured with the AS-OCT (AC depth (ACD)) after surgery. - anterior chamber depth in mm | anterior chamber depth in mm Distance from corneal endothelium to anterior surface of the lens | one week post operative | |
Secondary | other biometric parameters measured with the AS-OCT, | Parameter Unit Iris thickness µT Iris curvature µC AC width µC Angle opening distance µO Angle recess area µR Trabecular iris angle Degrees Lens vault µV |
1,3,6, month postoperative | |
Secondary | intra ocular pressure | intra ocular pressure in mm hg | 1,3,6, month postoperative |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06000865 -
Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE
|
N/A | |
Recruiting |
NCT06278597 -
Automatic Evaluation of the Anterior Chamber Angle Width by a New Non-contact Optical Device
|
N/A | |
Active, not recruiting |
NCT04271709 -
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
|
N/A | |
Recruiting |
NCT03274024 -
The Asia Primary Tube Versus Trab (TVT) Study
|
N/A | |
Completed |
NCT04552964 -
Assessment of the Impact of an add-on and Its Smartphone Application on the Daily Management of Glaucoma
|
N/A | |
Recruiting |
NCT01957267 -
Functional and Structural Imaging for Glaucoma
|
||
Active, not recruiting |
NCT04624698 -
iStent Inject New Enrollment Post-Approval Study
|
N/A | |
Completed |
NCT04020705 -
The Efficacy of Citicoline in Eyedrops (OMK1) in Reducing the Progression of Glaucoma
|
N/A | |
Completed |
NCT03150160 -
Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma
|
Phase 4 | |
Not yet recruiting |
NCT05581498 -
Glaucoma Exercise as Medicine Study (GEMS).
|
N/A | |
Recruiting |
NCT02921568 -
Side-by-Side Comparison of P200TE and Spectral OCT/SLO on Diseased Eyes
|
N/A | |
Active, not recruiting |
NCT02901730 -
Clinical Study of LPI With Different Laser Wavelengths
|
N/A | |
Completed |
NCT02955849 -
A Trial of China Laser and Surgery Study Glaucoma in Rural China
|
Early Phase 1 | |
Recruiting |
NCT02554214 -
Pilot Clinical Trial on a New Adjustable Glaucoma Drainage Device
|
N/A | |
Recruiting |
NCT02471105 -
Investigation of IOP and Tolerability of Bimatoprost 0.01% and Tafluprost Unit Dose Preservative Free 15 Microgram/ml
|
Phase 4 | |
Active, not recruiting |
NCT02390284 -
Stop Retinal Ganglion Cell Dysfunction Study
|
Phase 3 | |
Completed |
NCT02246764 -
Study of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
|
Phase 3 | |
Completed |
NCT02653963 -
Triamcinolone for Ahmed Glaucoma Valve
|
N/A | |
Completed |
NCT02390245 -
Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study
|
N/A | |
Completed |
NCT02520674 -
Glaucoma Screening With Smartphone Ophthalmology
|
N/A |