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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03402802
Other study ID # IRB00160532
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 1, 2019
Est. completion date August 25, 2021

Study information

Verified date August 2021
Source Johns Hopkins University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The study will monitor how often persons use eye drops that are prescribed after glaucoma surgery and will compare the adherence with drop use to the success rate of the surgery.


Description:

Trabeculectomy is the most common operation performed for all forms of glaucoma. The procedure depends upon appropriately modulated healing of the conjunctiva and sclera, a major component of which is delivery of frequent topical corticosteroid eye drops (prednisolone acetate 1%) by the patient, initially every 2 hours when awake for 1-2 weeks, then in tapering frequency over the 6 weeks after surgery. While the initial success of trabeculectomy at one year varies from 55-80% depending upon the criteria chosen to measure outcome, improvements in success would benefit hundreds of thousands of patients in the USA yearly. There is reasonable evidence that steroid drops benefit success, but there is essentially no data on how successfully patients remember to take the drops. In previous research, investigators have shown that glaucoma patients take only half to two-thirds of prescribed drops. An electronic monitoring device is now available that can fit the eye drop bottle used in steroid drops, accurately measuring the time and date of each drop taken. The investigators can further assess the accuracy with which each patient can deliver a drop from the bottle being monitored in a clinic session directly onto the eye's surface by observing their performance. The proposal's hypothesis is that the one year success rate of the procedure will be related to the adherence to steroid drop taking by patients. The outcome will have two important benefits. First, if adherence is less than ideal (which is very likely), then those with greater adherence will have more successful surgery, confirming that steroid treatment is effective. This has only been measured once, 30 years ago, at a time when trabeculectomy was being performed quite differently. If steroid treatment is not related to success, a change in preferred practice patterns is in order. If steroid treatment is related to success and adherence is variable, the investigation will have proven means to increase adherence through reminder systems, which have shown in past randomized clinical trial to be effective.


Recruitment information / eligibility

Status Completed
Enrollment 92
Est. completion date August 25, 2021
Est. primary completion date August 25, 2021
Accepts healthy volunteers
Gender All
Age group 21 Years to 100 Years
Eligibility Inclusion Criteria: - Persons having glaucoma surgery Exclusion Criteria: - Persons not eligible for glaucoma surgery, including pregnant females persons allergic to standard postoperative eye drops

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
monitoring of adherence with medication
persons taking routine postoperative eye drops will have their frequency of drop taking monitored

Locations

Country Name City State
United States Johns Hopkins University Baltimore Maryland

Sponsors (1)

Lead Sponsor Collaborator
Johns Hopkins University

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary adherence rate frequency of taking eye drops 6 weeks
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