Glaucoma Clinical Trial
— ALPIECAOfficial title:
Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies An Anterior Segment Optical Coherence Tomography Study
Purpose:
To evaluate short-term angle opening after argon peripheral iridoplasty using AS-OCT and to
report its complications at 1-week and 1-month follow up in patients that did not achieve a
satisfactory clinical angle opening despite patent laser peripheral iridotomy.
Design:
Prospective, Interventional case series
Subjects:
Patients with an occludable angle in more than two quadrants in dark room indentation
gonioscopy and patent iridotomies of at least 2 weeks, with assessment of persistent angle
closure aetiology by ultrabiomicroscopy and A-scan ultrasound are included.
Patients will undergo complete examination and AS-OCT before ALPI, one week and one month
after it. We analyzed the images in a masked manner and took the angle measurements (AOD500,
AOD 750, TISA500, TISA750, ARA500, ARA 750, Lens vault) at 0° and 180° as the main outcome
measure to determine effectiveness.
Status | Completed |
Enrollment | 10 |
Est. completion date | January 2013 |
Est. primary completion date | November 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients with an occludable angle in more than two quadrants in dark room dynamic gonioscopy and patent iridotomies of at least 2 weeks were included - A supplemental diagnosis regarding the etiology of persistent angle closure by ultrabiomicroscopy and A-scan ultrasound was obtained. Exclusion Criteria: - Patients with synechiae of more than one quadrant - Advanced glaucomatous damage - Prompt cataract surgery plans and those who did not wish to participate were excluded |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Mexico | "Fundación Conde de Valenciana" Ophthalmology Institute | Mexico City | Obrera |
Lead Sponsor | Collaborator |
---|---|
Instituto de Oftalmología Fundación Conde de Valenciana |
Mexico,
Fu J, Qing GP, Wang NL, Wang HZ. Efficacy of laser peripheral iridoplasty and iridotomy on medically refractory patients with acute primary angle closure: a three year outcome. Chin Med J (Engl). 2013 Jan;126(1):41-5. — View Citation
Ritch R, Tham CC, Lam DS. Argon laser peripheral iridoplasty (ALPI): an update. Surv Ophthalmol. 2007 May-Jun;52(3):279-88. Review. — View Citation
Ritch R, Tham CC, Lam DS. Long-term success of argon laser peripheral iridoplasty in the management of plateau iris syndrome. Ophthalmology. 2004 Jan;111(1):104-8. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Angle Aperture | Angle opening measured by anterior segment optical coherence tomography | 1 month | No |
Secondary | Complications | complications reported by patient and/or examiner | 1 month | Yes |
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