Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma

Glaucoma Clinical Trial

Official title:

Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01266343
• Other study ID #: 99018
• Status: Completed
• Phase: N/A
• First received: December 22, 2010
• Last updated: December 23, 2010
• Start date: January 2007
• Est. completion date: December 2009

Study information

• Verified date: December 2010
• Source: Taipei Medical University WanFang Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

The investigators wanted to reported the results of immediate anterior chamber paracentesis (ACP), compared to Mannitol infusion, in patients with acute primary angle-closure glaucoma (PACG). In this study, the investigators first divided patients into three sub-groups according to their initial intraocular pressure (IOP) for analyzing the differences of IOP control, severity of corneal edema, waiting time for laser peripheral iridotomy (LPI), and visual outcome between ACP and Mannitol infusion.

Description:

The investigators demonstrated that ACP could be first considered in patients with initial IOP between 45 to 60 mmHg because it provided better visual outcome than Mannitol infusion through the rapid stabilization of the anterior segment, which was achieved by rapid IOP control, better corneal edema regression, shortening waiting time for LPI. However, ACP should be considered in patients with the initial IOP of 60mmHg and higher only when Mannitol was contraindicated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• first attack of acute PACG;

• initial presenting IOP was higher than 45 mmHg;

• diagnosis confirmed by gonioscopic examination;

• patients within 48 hours of symptom onset.

Exclusion Criteria:

• been incompletely followed up within 2 weeks;

• been using anti-glaucomatous medication before ACP or Mannitol infusion;

• previous intraocular surgeries on the same eye;

• contraindication for Mannitol;

• history of other vision-threatening ocular diseases.

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Acute Disease
• Acute Primary Angle-closure Glaucoma
• Glaucoma
• Glaucoma, Angle-Closure

Locations

Country	Name	City	State
Taiwan	Taipei Medical University - WanFang Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
Taipei Medical University WanFang Hospital

Country where clinical trial is conducted

Taiwan,