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NCT01115218 Clinical Trial

The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

Glaucoma Clinical Trial

Official title:
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01115218
Other study ID # MeVeTra-2009
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 2009
Est. completion date March 2012

Study information
Verified date November 2018
Source University of Cologne
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Recruitment information / eligibility
Status Completed
Enrollment 62
Est. completion date March 2012
Est. primary completion date January 2010
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- patients with glaucoma with a trabeculectomy required

- 60 eyes of 60 patients, The ratio of female / male is not involved.

- Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).

- age of at least 18 years

Exclusion Criteria:

- all patients not included in the group of inclusion criteria.

- less than 50yl anterior chamber fluid could be collected during the operation.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Trabeculectomy
Trabeculectomy with mitomycin C

Locations
Country Name City State
Germany University Eye Hospital, University of Cologne Cologne NRW

Sponsors (1)
Lead Sponsor Collaborator
University of Cologne

Country where clinical trial is conducted

Germany, 

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