Glaucoma Clinical Trial
Official title:
Effects of Common Topical Glaucoma Therapy on Optic Nerve Head Blood Flow Autoregulation During Increased Arterial Blood Pressure and Artificially Elevated Intraocular Pressure in Healthy Humans
Background
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in
perfusion pressure. The existence of an effective autoregulation in the optic nerve
circulation has been shown in animals and humans. The exact mechanism behind this
autoregulation is still unknown. The motive for the investigation of optic nerve head (ONH)
blood flow autoregulation is to enhance the understanding of pathologic eye conditions
associated with ocular vascular disorders. To clarify the regulatory mechanisms of ONH
microcirculation is of critical importance to understand the pathophysiology of glaucoma,
because there is evidence that glaucoma is associated with optic nerve head ischemia.
Several studies indicate that a disturbed autoregulation might contribute to glaucomatous
optic neuropathy. Currently, five classes of intraocular pressure (IOP) reducing drugs are
available for topical therapy in patients with glaucoma or elevated intraocular pressure.
These drugs have also vasoactive properties, which may influence both the resting ocular
circulation and the autoregulatory mechanisms of blood flow during changes in ocular
perfusion pressure.
Study objective
To investigate the influence of common topical glaucoma therapy on ONH blood flow regulation
during changes in IOP and systemic arterial blood pressure.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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