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Glaucoma clinical trials

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NCT ID: NCT00872651 Completed - Ocular Hypertension Clinical Trials

Travoprost 0.004%/Timolol 0.5% Versus Latanoprost 0.005%/Timolol in Chinese Patients With Open-Angle Glaucoma or Ocular Hypertension

Start date: January 2010
Phase: Phase 3
Study type: Interventional

Eligible patients will be randomized in a 1.1 ratio to receive Travoprost 0.004%/timolol 0.5% once daily or Latanoprost 0.005%/Timolol 0.5% once a day for 8 Weeks. The study treatments will be compared for mean diurnal intraocular pressure (IOP) change from baseline at Week 8. Safety parameters measured at 4 study visits: ocular signs, visual acuity, dilated fundus, cardiovascular parameters (blood pressure and pulse), and adverse events.

NCT ID: NCT00869141 Completed - Glaucoma Clinical Trials

Earlier Intraocular Pressure Control After Ahmed Glaucoma Valve Implantation for Glaucoma

Start date: March 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the occurrence rate of the high pressure phase and the final pressure outcomes between patients treated with glaucoma medication prior to the expected onset of the high pressure phase to those patients who have glaucoma medication started at the onset of the high pressure phase. The investigators hypothesize that if glaucoma medications are started prior to the expected onset of high pressure phase, the high pressure phase will not occur as frequently and the ultimate pressure level will be lower than if the glaucoma medications are started at the onset of this phase.

NCT ID: NCT00868894 Completed - Ocular Hypertension Clinical Trials

Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension

Start date: March 2009
Phase: Phase 1/Phase 2
Study type: Interventional

To investigate safety, efficacy, and the dose-response relationship of DE-104 in lowering intraocular pressure in Japanese and Non-Japanese subjects with primary open-angle glaucoma or ocular hypertension.

NCT ID: NCT00863018 Completed - Glaucoma Clinical Trials

Corneal Endothelium After Glaucoma Surgery

Start date: August 2003
Phase: N/A
Study type: Observational

The purpose of this trial is to study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and Ahmed glaucoma valve implant surgery prospectively. Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area will be analyzed and compared to the baseline and between the types of the surgeries.

NCT ID: NCT00856622 Completed - Glaucoma Clinical Trials

A Study Demonstrating The Effect Of Latanoprost In Combination With Timolol, Latanoprost Alone And Timolol Alone On Eye Pressure In Open Angle Glaucoma Or Ocular Hypertension In Patients

Start date: August 1997
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate that fixed combination of latanoprost and timolol (PhXA41) has better IOP lowering effect than the individual monotherapies.

NCT ID: NCT00853905 Completed - Glaucoma Clinical Trials

Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?

Start date: February 2009
Phase: Phase 2/Phase 3
Study type: Interventional

The investigators hypothesize that intracameral Triesence during glaucoma surgery will provide lower intraocular pressure through better control of ocular inflammation, thus leading to a more successful filtering procedure.

NCT ID: NCT00853073 Completed - Glaucoma Clinical Trials

Does Adding Bevacizumab Therapy in Glaucoma Surgery Improve the Success of Needle Bleb Revisions?

Avastin
Start date: February 2009
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to see if a new add on (or adjunctive) therapy used in glaucoma surgery improves the success of needle bleb revisions.

NCT ID: NCT00848536 Completed - Ocular Hypertension Clinical Trials

Efficacy Study of Travoprost APS Versus TRAVATAN

Start date: March 2009
Phase: Phase 3
Study type: Interventional

A Multi-Center Double-masked Study of the Safety and Efficacy of Travoprost APS Compared to TRAVATAN in Patients with Open-angle Glaucoma or Ocular Hypertension

NCT ID: NCT00847483 Completed - Glaucoma Clinical Trials

Comparison of Latanoprost With Travoprost and Bimatoprost in Patients With Elevated IOP. A 12-weeks, Masked Evaluator, Phase IV Multi-center Study in the US

XLT
Start date: January 2002
Phase: Phase 4
Study type: Interventional

Compare the IOP lowering properties of latanoprost, travoprost and bimatoprost

NCT ID: NCT00846989 Completed - Glaucoma Clinical Trials

Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension

Start date: January 2009
Phase: Phase 1/Phase 2
Study type: Interventional

This purpose of this study is to access the efficacy, tolerability and safety of RKI983 (0.05% and 0.10%) ophthalmic solution bid versus once daily latanoprost 0.005%, in patients with POAG or ocular hypertension.