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Glaucoma clinical trials

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NCT ID: NCT02507687 Completed - Ocular Hypertension Clinical Trials

Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension

Start date: August 27, 2015
Phase: Phase 3
Study type: Interventional

This study will evaluate the intraocular pressure (IOP)-lowering effect and safety of bimatoprost SR compared with selective laser trabeculoplasty in patients with open-angle glaucoma or ocular hypertension who are not adequately managed with topical IOP-lowering medication for reasons other than medication efficacy (e.g., due to intolerance or nonadherence).

NCT ID: NCT02490267 Completed - Clinical trials for Paediatrics With Glaucoma

Quality of Life in Children Glaucoma and Cataract

Start date: June 2014
Phase: N/A
Study type: Observational

The management of childhood glaucoma (CG), childhood cataract (CC) and other birth defects affecting the eyes requires frequent hospital attendances and often multiple surgical and medical interventions, and are often associated with poor vision. Chronic medical conditions and vision impairment can affect quality of life (QoL). The QoL of children with the above conditions has not previously been evaluated.

NCT ID: NCT02466399 Completed - Glaucoma Clinical Trials

POLAT-001 Compared to Latanoprost Ophthalmic Solution in Patients With Ocular Hypertension and Open-angle Glaucoma

Start date: July 2015
Phase: Phase 2
Study type: Interventional

This is an open-label, randomized, multi-center, active-controlled parallel-comparison of POLAT-001 to latanoprost ophthalmic solution in patients with ocular hypertension and primary open-angle glaucoma.

NCT ID: NCT02448875 Completed - Open Angle Glaucoma Clinical Trials

Clinical Evaluation of Visco-Assisted CyPass® Micro-Stent Implantation in Patients With Open Angle Glaucoma

ViscoPass
Start date: June 21, 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and effectiveness of the use of visco-assisted CyPass® Micro-Stent implantation for the lowering of intraocular pressure (IOP) in subjects who have open angle glaucoma (OAG).

NCT ID: NCT02434692 Completed - Clinical trials for Primary Open Angle Glaucoma (POAG)

Safety and Performance Study of the ARGOS-IO (Intraocular) System in Patients With Primary Open Angle Glaucoma (POAG)

Start date: May 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and performance of the ARGOS-IO system in patients with POAG and indicated cataract surgery.

NCT ID: NCT02434250 Completed - Cataract Clinical Trials

Selective Laser Trabeculoplasty After Failed Phacoemulsification With Eximer Laser Trabeculectomy

SLT
Start date: May 2015
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the efficacy of selective laser trabeculoplasty after a prior failed phacoemulsification and Eximer Laser Trabeculectomy.

NCT ID: NCT02406833 Completed - Clinical trials for Primary Open Angle Glaucoma

Phase I Dose Escalation Study to Investigate the Safety of ISTH0036 in Subjects With Glaucoma Undergoing Trabeculectomy

Start date: April 2015
Phase: Phase 1
Study type: Interventional

This study evaluates the addition of ISTH0036, an antisense oligonucleotide against TGF-β2, to glaucoma filtration surgery (trabeculectomy). The treatment aims at improving the surgery outcome by prevention of excessive scarring and trabecular meshwork transformation.

NCT ID: NCT02405884 Completed - Glaucoma Clinical Trials

Intraocular Pressure and Hemodialysis Midwestern Brazil

EHPIOBRAZIL
Start date: January 2014
Phase: N/A
Study type: Interventional

Objective: To evaluate the variation in intraocular pressure in patients with chronic kidney disease, according to the time interval between hemodialysis sessions and to the influence of weight and blood pressure on intraocular pressure. Methods: This was a cross-sectional study in which 78 eyes of 39 patients on hemodialysis, at the Santa Casa de Misericordia de Goiânia hospital, were analyzed in June 2014. Patients were divided into groups according to the days on which they underwent hemodialysis. The mean, standard deviation, and median of the intraocular pressure, blood pressure, and weight were calculated. P-values <0.05 were considered statistically significant.

NCT ID: NCT02396316 Completed - Clinical trials for Glaucoma, Neovascular

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

VEGA
Start date: April 2015
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of the administration of aflibercept by intravitreal injection in comparison to sham to control intraocular pressure in patients with neovascular glaucoma.

NCT ID: NCT02390245 Completed - Cataract Clinical Trials

Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study

Start date: September 2014
Phase: N/A
Study type: Interventional

The goal is to conduct a 5-year prospective, randomized controlled trial to test an innovative, community-based intervention using posterior and anterior fundus photography of the optic nerve and macula and intraocular eye pressure measurements to improve access and utilization of eye care to detect, treat, and manage high-risk patients with previously undiagnosed glaucoma and other eye diseases. Research shows that subject failure to attend follow-up eye care appointments diminishes any previous benefits of community screenings for glaucoma. Greater adherence to follow-up visits can reduce glaucomatous blindness.