Glaucoma, Open-Angle Clinical Trial
Official title:
The Impact of Topical Prostaglandin Analogs on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma
Verified date | February 2021 |
Source | Maisonneuve-Rosemont Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to determine the influence of topical prostaglandin analog (PGA) medication on corneal biomechanical properties in patients undergoing PGA treatment for open-angle glaucoma.
Status | Completed |
Enrollment | 35 |
Est. completion date | November 16, 2016 |
Est. primary completion date | June 30, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years to 85 Years |
Eligibility | Inclusion Criteria: - patients with bilateral open angle glaucoma on monotherapy with topical PGA medication in both eyes Exclusion Criteria: - corneal disease (such as Fuchs' endothelial dystrophy or keratoconus) - past history of corneal trauma or surgery (including refractive surgery) that may affect hysteresis measurements - contact lens wearers - uncontrolled glaucoma or advanced visual field (VF) damage (mean defect < -12.0 db) - patients taking systemic prostaglandin medication, non-steroidal anti-inflammatory drugs, or undergoing hormone replacement therapy |
Country | Name | City | State |
---|---|---|---|
Canada | Montreal Glaucoma Institut | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Maisonneuve-Rosemont Hospital |
Canada,
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* Note: There are 31 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The Corneal Hysteresis (in mmHg) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from the Reichert Ocular Response Analyzer (ORA) | 12 weeks | ||
Secondary | The intraocular pressure (in mmHg) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from Goldmann tonometry | 12 weeks | ||
Secondary | The corneal thickness (in µm) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from pachymetry | 12 weeks | ||
Secondary | The Corneal Resistance Factor (in mmHg) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from the Reichert Ocular Response Analyzer (ORA) | 12 weeks |
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