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Glaucoma, Open-Angle clinical trials

View clinical trials related to Glaucoma, Open-Angle.

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NCT ID: NCT06455683 Not yet recruiting - Ocular Hypertension Clinical Trials

The A D A G I O Study

Start date: June 2024
Phase:
Study type: Observational

This study aims to investigate the effect of different types of glaucoma surgery on aqueous dynamics parameters (IOP, aqueous flow rate, trabecular outflow facility and uveoscleral outflow) in patients with uncontrolled open angle glaucoma or ocular hypertension (OHT)

NCT ID: NCT06441643 Not yet recruiting - Ocular Hypertension Clinical Trials

Next Generation Rocklatan

Start date: September 2024
Phase: Phase 2
Study type: Interventional

The purpose of this two-stage clinical trial is to assess the safety and hypotensive efficacy of AR-17043 and PG043 ophthalmic solutions in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).

NCT ID: NCT06407973 Not yet recruiting - Clinical trials for Primary Open Angle Glaucoma

A Clinical Trial Comparing the OMNI Surgical System to Standard Medical Treatment in Pseudophakic Eyes

EVOLVE
Start date: June 30, 2024
Phase: Phase 4
Study type: Interventional

A Randomized Clinical Trial of Ab Interno Canaloplasty and Trabeculotomy with the OMNI® Surgical System Compared to Standard Medical Treatment in Pseudophakic Patients with Primary Open Angle Glaucoma (EVOLVE)

NCT ID: NCT06394973 Not yet recruiting - Glaucoma Clinical Trials

Efficacy and Safety Assessment of T4090 Ophthalmic Solution Versus Rhopressa® Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension

Start date: July 2024
Phase: Phase 2
Study type: Interventional

The main purpose is to compare the ocular hypotensive efficacy and safety of two concentrations of T4090 (Kinezodianone R HCl 0.2% and 0.3%) ophthalmic solution with Rhopressa® ophthalmic solution

NCT ID: NCT06333236 Not yet recruiting - Glaucoma Clinical Trials

Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma

Start date: March 25, 2024
Phase: N/A
Study type: Interventional

Aim of this study is to investigate the administration effects of the combination of citicoline 40mg/ml and nicotinamide 15mg/ml oral solution (Kron®) on short term improvement in inner retinal function, bioelectrical activity of the visual cortex and visual function.

NCT ID: NCT06313749 Not yet recruiting - Open Angle Glaucoma Clinical Trials

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

Start date: April 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to show non-inferiority of the MIMS® device/procedure with Mitomycin-C, in terms of its surgical success rate, compared to trabeculectomy with Mitomycin-C in subjects diagnosed with primary open angle glaucoma, whose intraocular pressure is not controlled despite polypharmacy. Eligible screened participants will undergo the MIMS® procedure and will be followed for a period of 12 months in this single-arm study. Investigators will compare the results of this study to the surgical success rate of traditional trabeculectomy with Mitomycin-C.

NCT ID: NCT06289491 Not yet recruiting - Glaucoma Clinical Trials

Randomized Trial of Hydrus Microstent Versus Goniotomy

Start date: April 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate open-angle glaucoma. The main questions it aims to answer are: - How do the intraocular pressure lowering effects of these three microinvasive glaucoma surgeries compare? - How do the safety profiles of these three microinvasive glaucoma surgeries compare? Participants will be randomized to one of these three microinvasive glaucoma surgeries in combination with cataract surgery.

NCT ID: NCT06267274 Not yet recruiting - Ocular Hypertension Clinical Trials

A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes

Start date: April 1, 2024
Phase: Phase 1
Study type: Interventional

A randomized, double-blind, parallel-group, two-arm, multiple dose, multicenter, clinical endpoint bioequivalence study

NCT ID: NCT06240312 Not yet recruiting - Clinical trials for Glaucoma, Open-Angle

Optic Nerve Head Strain as Biomarker for Glaucoma

Start date: July 1, 2024
Phase: N/A
Study type: Interventional

The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.

NCT ID: NCT06230393 Not yet recruiting - Open Angle Glaucoma Clinical Trials

An Extension Trial for Patients With Open-Angle Glaucoma Who Participated in the DF6-CL-20-01 Protocol.

Start date: March 1, 2024
Phase:
Study type: Observational

The purpose of this study is to evaluate long term safety and effectiveness of the STREAMLINE® SURGICAL SYSTEM