Gingivitis Clinical Trial
Official title:
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients: a Prospective, Double-blind, Randomized, Clinical Study
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions. However, studies could show that an increase of certain inflammatory cytokines during orthodontic treatment correlated with a higher risk of root resorption. Moreover, it has been shown that orthodontic treatment leads to a dysbiosis of the oral microbiome especially during the first 3 months of the orthodontic treatment. This could be a potential risk factor as the inflammation of periodontitis during an orthodontic treatment could favor root resorption and progressive destruction of the periodontal apparatus. Probiotics are already used successfully as an adjuvant therapy in the treatment of periodontitis to improve clinical parameters and to reduce local inflammation. However, there are only a few studies that investigated the influence of probiotics during an orthodontic treatment. Therefore, the aim of our study is to investigate if the daily intake of lozenges containing probiotics versus placebo lozenges during the first 3 months of orthodontic treatment with fixed appliances can improve clinical parameters, reduce local inflammation, systemic inflammation and prevent a dysbiosis of the oral microbiome.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05568290 -
Interleukin-38 Levels in Individuals With Periodontitis
|
||
| Completed |
NCT04402996 -
Meteorin-like Levels in Individuals With Periodontitis
|
||
| Not yet recruiting |
NCT06016023 -
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
|
||
| Not yet recruiting |
NCT05497895 -
The Assessment of Clinical Efficacy of Topical Application of 5% Thymoquinone Gel for Gingivitis Patients
|
Early Phase 1 | |
| Completed |
NCT02884817 -
Essential Oil+ELA, Plaque and Gingivitis
|
Phase 4 | |
| Completed |
NCT02633345 -
Effects on Tablets Containing Probiotic Candidate Strains
|
N/A | |
| Completed |
NCT02552589 -
Effect of Toothpaste on the Reduction of Plaque and Inflammation
|
N/A | |
| Unknown status |
NCT01956656 -
Efficacy Of Lotus Leaves In Management Of Plaque Induced Gingivitis
|
N/A | |
| Completed |
NCT02515929 -
Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs
|
Phase 4 | |
| Completed |
NCT02235532 -
Effects of Aloe Vera Toothpaste on Periodontal Parameters
|
N/A | |
| Completed |
NCT02980497 -
Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study
|
N/A | |
| Completed |
NCT02508987 -
Obesity and Oxidative Stress in Patients With Different Periodontal Status
|
N/A | |
| Completed |
NCT01941797 -
Experimental Peri-implant Mucositis in Humans
|
N/A | |
| Completed |
NCT01593540 -
Clinical Examination of Metal Free Interdental Brushes
|
Phase 4 | |
| Unknown status |
NCT01197105 -
Evaluation Study of a Mouthwash Based on Schinus Terebinthifolius to Treat Gingivitis in Children
|
Phase 1/Phase 2 | |
| Completed |
NCT01236963 -
Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation
|
N/A | |
| Completed |
NCT02102295 -
Effects of Antioxidant Dentifrice on Gingivitis
|
Phase 3 | |
| Completed |
NCT06140784 -
A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices
|
N/A | |
| Completed |
NCT02937636 -
To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population
|
N/A | |
| Completed |
NCT06212908 -
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer
|
N/A |