Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects.

Gingival Recession Clinical Trial

Official title:

Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects. A Controlled Randomized Clinical Trial.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04032405
• Other study ID #: CukurovaU-PER
• Status: Completed
• Phase: N/A
• Start date: November 1, 2017
• Est. completion date: March 30, 2019

Study information

• Verified date: July 2019
• Source: Cukurova University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Aim: The aim of this study was to determine whether the combined connective tissue graft (CTG) with injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF) improved root coverage of deep Miller Class I or II gingival recessions compared to CTG alone with CAF.

Methods: Seventy-two patients with Miller class I and II gingival recessions were enrolled. Thirty-six patients were randomly assigned to the test group (CAF+CTG+i-prf) or control group (CAF+CTG). Clinical evaluations were made at 6 months

Recruitment information / eligibility

• Status: Completed
• Enrollment: 72
• Est. completion date: March 30, 2019
• Est. primary completion date: September 25, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• =19 years of age,

• Periodontally and systemically healthy,

• FMPS and FMBS <15%,

• Presence of deep Miller class I and II gingival recession defect (=3 mm in depth) at the buccal aspect of incisors,

Exclusion Criteria:

Smoking,

• Contraindications for surgery,

• Presence of recession defects associated with caries, deep abrasion, restoration or pulpal pathology.

Related Conditions & MeSH terms

• Gingival Recession

Intervention

Procedure:
• CAF+CTG+i-prf
combined connective tissue graft (CTG) and injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF)

Locations

Country	Name	City	State
Turkey	Cukurova University	Adana	Balcali

Sponsors (1)

Lead Sponsor	Collaborator
Cukurova University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	gingival recession depth	the distance between the CEJ and gingival margin-measurements were performed at the midbuccal aspect of the teeth, by manual probe and were rounded up to the nearest millimetre	six months
Primary	Keratized tissue height	measured from the mucogingival junction to the gingival margin-measurements were performed at the midbuccal aspect of the teeth, by manual probe and were rounded up to the nearest millimetre	six months