Preventing Recurrent Gestational Diabetes With Metformin — PRoDroME  

Gestational Diabetes Mellitus Clinical Trial

Official title: Preventing Recurrent Gestational Diabetes Mellitus With Early Metformin Intervention

Status Recruiting

Clinical Trial Summary

Study Hypothesis: Intervention with metformin therapy early in pregnancy will prevent gestational diabetes mellitus recurring in previously affected pregnancies.

Clinical Trial Description

Gestational diabetes mellitus (GDM) is a common medical complication of pregnancy and is associated with increased risks to mother and baby. The incidence is increasing reflecting changing pre-gravid female demographics. Once one pregnancy is complicated by GDM, subsequent pregnancies are more likely to be affected by the same condition. This reported risk of recurrence is estimated to range between 35 and 80%, with non-caucasian ethnicity being the strongest predictor of GDM recurrence. Evidence regarding further predictors of recurrent GDM is conflicting and measures that might prevent recurrence need exploring.

Metformin is commonly used in the treatment of established GDM and has been shown to reduce the incidence of GDM in the context of polycystic ovarian syndrome. ;

Related Conditions & MeSH terms

• Diabetes Mellitus
• Diabetes, Gestational
• Gestational Diabetes Mellitus

• NCT number: NCT02394158
• Study type: Interventional
• Source: Imperial College London
• Contact: Stephen Robinson, FRCP, MD
• Phone: 0203 312 1253
• Email: stephen.robinson@imperial.nhs.uk
• Status: Recruiting
• Phase: Phase 4
• Start date: January 27, 2015
• Completion date: September 30, 2019