Gestational Diabetes Mellitus Clinical Trial
Official title:
Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes in Gestational Diabetes
Verified date | June 2015 |
Source | University of Colorado, Denver |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Interventional |
A better understanding of the optimal diet for women with gestational diabetes is fundamental to the management of this rapidly growing problem in pregnancy. Careful comparison studies of the current low- carbohydrate, higher-fat diet versus a diet higher in complex carbohydrate but lower in fat is critical in order to determine which diet results in a more favorable maternal 24-hour glucose, lipid, and inflammatory profile, all of which directly effect optimal fetal growth and may influence the future health of the offspring.
Status | Completed |
Enrollment | 35 |
Est. completion date | February 2015 |
Est. primary completion date | February 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria:Inclusion Criteria. Potential participants will be = 0-36 years old,
which includes the offspring of the pregnant mothers with GDM. Pregnant women will be
between the ages of 18-40 years and will have a BMI of 26 - 35 kg/m2 at the time of
diagnosis, a singleton pregnancy, and will not be taking medication for their GDM on
entrance to the study. Subjects will have been diagnosed with GDM according to the
criteria established by the ADA and the ACOG (19;35;53), specifically, they will meet the
following criteria: - A 50-gram Glucola in which the one hour reading is >200 mg/dL and the FBG is >95 mg/dL - Two abnormal values on a 100-gram 3 hour glucose tolerance test based on the Coustan and Carpenter criteria as adopted by the ADA and Fourth International Workshop on Gestational Diabetes (76;77): - Fasting > or = to 95 mg/dL but <126 mg/dL - 1 hr >/= 180 mg/dL - 2 hr >/= 155 mg/dL - 3 hr >/=140 mg/dL Exclusion Criteria:Those women with overt diabetes and those suspected of having preexisting diabetes by any of the following criteria will be excluded, including: - Fasting glucose >110 mg/dL, due to the high likelihood of rapidly failing diet and requiring medical treatment (35). - Random glucose > 200 mg/dL - Glycosylated hemoglobin A1C > 6.5 - Non-English speaking patient - Fasting TG > 400 mg/dL Women who smoke will be excluded since this is the leading cause of low birth weight. In addition, women with other risk factors for placental insufficiency, including hypertension requiring beta-blocker treatment, renal disease, thrombophilias, preeclampsia, steroid use, history of pancreatitis or infectious disease such as hepatitis, or intrauterine growth restriction will be excluded. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | University of Colorado, Anschutz Medical Campus | Aurora | Colorado |
Lead Sponsor | Collaborator |
---|---|
University of Colorado, Denver | Kaiser Permanente |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Glucose area-under-the-curve | The average glucose area-under-the-curve over 3 days, calculated using 24-hour continuous glucose monitoring | During 3 days of each diet treatment | No |
Secondary | Infant Adiposity | Infant adiposity measured using Pea Pod | 2 weeks after birth | No |
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