Gestational Diabetes Mellitus Clinical Trial
Official title:
Gestational Diabetes Mellitus: Insulin or Oral Hypoglycemic Agents?
Gestational diabetes mellitus takes place in 2 steps. First, it is the consequence of insulin
resistance due to the modifications of the pregnancy hormonal environment, and second, of the
deficiency of the beta cells of the pancreas to respond by a sufficient insulin secretion.
This physiopathology is closely connected to the one of type 2 diabetes. Insulin, indeed, can
remedy these 2 etiologies, but it is logical to think about using oral hypoglycemic agents
which have been created to treat them: they are a natural choice because they improve insulin
sensitivity (metformin, a biguanide) or insulin secretion (glyburide, a sulfonylurea). It
also seems natural to use them in combination, glyburide being added to metformin if needed.
OUR GENERAL RESEARCH HYPOTHESIS IS THAT: in pregnant women with gestational diabetes
mellitus, using both oral hypoglycemic agents (glyburide added to metformin if needed) allows
a glycemic control comparable to the one obtained with insulin, but with a better
acceptability from women and a better health status, diabetes treatment satisfaction and
well-being and a reduced postnatal depression.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06099574 -
A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
|
||
| Completed |
NCT02890693 -
Improving Cardio-metabolic and Mental Health in Women With Gestational Diabetes Mellitus and Their Offspring
|
N/A | |
| Completed |
NCT02744300 -
Balance After Baby Intervention for Women With Recent Gestational Diabetes
|
N/A | |
| Completed |
NCT02384226 -
User Testing and Feedback for a Mobile Health Program for Postpartum Women: A Pilot Study
|
||
| Completed |
NCT02436551 -
Gestational Diabetes in Central Asia: Prevalence and Management
|
||
| Recruiting |
NCT02275845 -
Medico-GDM Trial - Metformine to Prevent Gestational Diabetes Mellitus
|
Phase 3 | |
| Recruiting |
NCT04621396 -
The Next Generation Longitudinal Birth Cohort Diabetes Study
|
||
| Completed |
NCT01931280 -
A Transgenerational e-Intervention for Gestational Diabetics and Their Offspring
|
N/A | |
| Completed |
NCT01916694 -
Trial of Remote Evaluation and Treatment of Gestational Diabetes Mellitus
|
N/A | |
| Not yet recruiting |
NCT01637727 -
Long Term Effects of Gestational Diabetes Mellitus in a Population of Parous Women
|
N/A | |
| Completed |
NCT01565564 -
Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes
|
N/A | |
| Recruiting |
NCT00550979 -
Gestational Diabetes Mellitus and Implications for Cardiovascular Disease Risk
|
N/A | |
| Completed |
NCT00460018 -
Diet, Exercise, and Breastfeeding Intervention Program for Women With Gestational Diabetes (DEBI Trial)
|
Phase 2 | |
| Not yet recruiting |
NCT04915716 -
Effect of Fasting Time Before Cesarean Section on Neonatal Blood Glucose in Pregnant Women With Gestational Diabetes Mellitus
|
||
| Completed |
NCT04422821 -
Flash Glucose Monitoring in Gestational Diabetes Mellitus: Study Protocol for a Randomized Controlled Trial
|
N/A | |
| Recruiting |
NCT04369313 -
Effect of DCC on Neonatal Jaundice and Blood Gas Analysis in Infants Born to GDM Mothers
|
N/A | |
| Recruiting |
NCT05348863 -
SPARK- a Digital Platform to Improve Self-management of Gestational Diabetes
|
N/A | |
| Recruiting |
NCT04272840 -
The Impact of Glycemic Index Education on Lowering Dietary GI in Gestational Diabetes Mellitus
|
N/A | |
| Completed |
NCT02588729 -
A Mobile Smartphone Application to Promote a Healthy Diet and Physical Activity Among Pregnant Women With GDM - RCT
|
N/A | |
| Completed |
NCT01922791 -
Nutrition and Pregnancy Intervention Study
|
N/A |