Geriatric In-patients Clinical Trial
Official title:
Repetitive Transcranial Stimulation to Treat Depression and Anxiety in Senior Inpatients
Verified date | July 2022 |
Source | University of Alberta |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Many seniors admitted for rehabilitation have symptoms of depression and anxiety that need to be treated before they can effectively engage in rehabilitation therapy. Anti-depressant or anti-anxiety medications are often used but there are many reasons why alternative or adjunctive treatments may be desirable. Medications can take weeks to become effective, if they work at all. There are many potential side effects of medications, especially in an older population, including cognitive and other neurologic impairments. There is also an increasing resistance to a polypharmacy approach to treatment in this population. A low-risk, relatively non-invasive, easily applied and well-tolerated treatment to accelerate mood and anxiety disorder resolution would allow earlier and more effective engagement in rehabilitation therapy. This would in turn shorten lengths of stay and improve quality of life. Recently, trans-cranial direct current stimulation with 1-2 mA currents has been proposed as a potential innovative alternative treatment modality. This stimulation is safe, easy to use, relatively insensitive to electrode placement, and may have other beneficial cognitive effects. The stimulation device consists of two electrodes placed on either side of the head, a unit that provides the stimulation and wires that connect this unit to the electrodes will be used. The electrodes are held in place with a head band.
Status | Completed |
Enrollment | 60 |
Est. completion date | February 9, 2020 |
Est. primary completion date | February 9, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years and older |
Eligibility | Inclusion Criteria: - Patients above 65 years old - a Geriatric Depression Score above 4 - cognitively sound enough to give consent - know English well enough to understand the procedure Exclusion Criteria: - being treated for an infection |
Country | Name | City | State |
---|---|---|---|
Canada | Glenrose Rehabilitation Hospital | Edmonton | Alberta |
Lead Sponsor | Collaborator |
---|---|
University of Alberta | Centre for Aging and Brain Health Innovation, Glenrose Foundation |
Canada,
Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol. 2017 Jan;128(1):56-92. doi: 10.1016/j.clinph.2016.10.087. Epub 2016 Oct 29. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Length of stay | How long the patient is in hospital measured in days | average length of stay varies from 28 to 42 days | |
Secondary | Geriatric Depression Score | Survey assessing depression level of subject | applied within 1 week of admission and then at 3 and 5 weeks | |
Secondary | Geriatric Anxiety Score | Survey assessing anxiety level of subject | applied within 1 week of admission and then at 3 and 5 weeks | |
Secondary | Older Person Quality of Life Questionnaire | Survey assessing subject's impression of thier overall quality of life | applied within 1 week of admission and then at 3 and 5 weeks |