Genotoxicity Clinical Trial
Official title:
Effects of Diesel Combustion Generated Air Pollution on Cardiovascular Function and Oxidatively Damaged DNA in Healthy Volunteers
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM).
PM has a recognized important role in human health. There is a strong scientific consensus on
the independent association of PM and adverse cardiovascular and respiratory effects, as well
as cancer. It is reasonable to expect that the smaller particles (ultrafine particles, UFP)
may have an enhanced toxicity relative to other PM size fractions, due to physical properties
and potential to translocation beyond the lung.
A recent Danish report concluded that train conductors on a working day, and in two specific
diesel engine trains, are exposed to higher concentrations of diesel exhaust than by constant
stay in a busy street. Indeed, the average exposure for train conductors on such engines was
around 100,000-150,000 UFP per cm3 as compared with around 40,000 per cm3 on a busy street in
Copenhagen [1]. The aim of this study is to investigate if this occupational exposure is
associated with vascular and respiratory impairment and DNA damage.
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