Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football

Genetic Predisposition Clinical Trial

Official title:

Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05220969
• Other study ID #: SMEC_2019-20_003
• Status: Completed
• Start date: December 1, 2019
• Est. completion date: July 31, 2021

Study information

• Verified date: January 2022
• Source: St Mary's University College
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury. This score was then compared with the incidence of injury between those with high, medium and low risk scores for each injury. The influence of different rates of growth, stages of physical maturation and loading exposure were then also included in the risk model to see if any interaction effects could be observed between genetic risk score and susceptibility to injury in different categories of growth, maturation and loading exposure.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 95
• Est. completion date: July 31, 2021
• Est. primary completion date: July 31, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 12 Years to 40 Years

Eligibility

Inclusion Criteria:

• Elite male football players

Exclusion Criteria:

• Female
• non-elite

Related Conditions & MeSH terms

• Apophysitis
• Disease Susceptibility
• Genetic Predisposition
• Genetic Predisposition to Disease
• Ligament Injury
• Muscle Strain
• Tendon Injuries
• Wounds and Injuries

Intervention

Genetic:
• Total Genotype Risk Score
A total genotype risk score has been generated based on the results of previously observed genetic association studies

Locations

Country	Name	City	State
United Kingdom	Fulham Football Club	London	New Malden
United Kingdom	St Mary's University, Twickenham	London	Twickenham

Sponsors (2)

Lead Sponsor	Collaborator
St Mary's University College	Fulham Football Club

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fracture Injury Risk	Did the risk of fracture differ between total genotype risk score categories? was this affected by maturation?	8 Years
Primary	Non-Contact Injury Risk	Did the risk of non-contact injury differ between total genotype risk score categories? was this affected by maturation, and loading?	8 Years
Primary	Non-Contact Muscle Injury Risk	Did the risk of non-contact muscle injury differ between total genotype risk score categories? was this affected by maturation, and loading?	8 Years
Primary	Tendon Injury Risk	Did the risk of tendon injury differ between total genotype risk score categories? was this affected by maturation, and loading?	8 Years
Primary	Ligament Injury Risk	Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?	8 Years
Primary	Apophysitis Injury Risk	Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?	8 Years