Genetic Study of Obstructive Azoospermia

Status Recruiting

Clinical Trial Summary

In 1% of men with infertility, obstructive azoospermia (OA) may occur in congenital absence of the vas (CAVD) or idiopathic obstructive azoospermia . Many studies have shown that the pathogenic genes of OA are CFTR and ADGRG2 genes, and the inheritance mode is autosomal recessive. Although the conventional assisted reproductive technology(PESA/TESA) can help these patients have children, male patients who carry mutations of the disease-causing genes (CFTR and ADGRG2) will also pass on their mutations to the next generation, which will increase the risk of male offspring infertility. Therefore, genetic detection of CFTR and ADGRG2 genes is very necessary for CAVD patients before assisted reproduction. Genetic diagnosis plays a key role in preventing the disease to the offspring.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05631509
Study type	Observational
Source	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Contact	Ping Yuan, PhD
Phone	86-20-81332230
Email	kekeyp1983@163.com
Status	Recruiting
Phase
Start date	July 1, 2021
Completion date	December 31, 2025

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