Genetic Disease Clinical Trial
— MVPOfficial title:
Genetic and Phenotypic Characteristics of Mitral Valve Prolapse
NCT number | NCT03884426 |
Other study ID # | RC12_0143 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | December 2010 |
Est. completion date | December 2021 |
Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.
Status | Recruiting |
Enrollment | 1000 |
Est. completion date | December 2021 |
Est. primary completion date | December 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Patients of any age - with typical mitral valve prolapse - relatives examined during familial screening Exclusion Criteria: - Refusal of the patient |
Country | Name | City | State |
---|---|---|---|
France | Brest University Hospital | Brest | |
France | Nantes University Hospital | Nantes | |
France | Rennes University Hospital | Rennes |
Lead Sponsor | Collaborator |
---|---|
Nantes University Hospital | Rennes University Hospital, University Hospital, Brest |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Incidence of cardiac or clinical defects associated with MVP | Atrial septal defect, ventricular septal defect, patent ductus arteriosus, tricuspid or aortic valve abnormalities (prolapse, bicuspid AV…), coarctation, ascending aorta aneurysm | At Day 0 Follow-up will be carried out at 5 and 10 years | |
Primary | MVP defined by a superior displacement of at least 2 mm | MVP defined by a superior displacement of at least 2 mm | At Day 0 | |
Secondary | Comprehensive mitral valve apparatus characterization per size of items (leaflets, chordae, annulus) | Leaflets length ; Chordae length ; Annulus diameter | At Day 0 | |
Secondary | Comprehensive mitral valve apparatus characterization per other items (papillary muscle, ventricles) | Papillary muscles aspect ; Right Ventricle function ; Left Ventricle Ejection Fraction | At Day 0 | |
Secondary | Comprehensive mitral valve apparatus characterization per size of items (ventricle and atrium sizes) | Left ventricle and atrium sizes ; right ventricle size ; right Atrium size | At Day 0 | |
Secondary | Comprehensive mitral valve apparatus characterization per size of items | Leaflets thickness | At Day 0 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
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