Anesthesia Neurodevelopmental Impact in Congenital Scoliosis Children

General Anesthetics Toxicity Clinical Trial

Official title: Long-term Effect of General Anesthesia Before School Age on Neurodevelopment in Children With Congenital Scoliosis

Status Recruiting

Clinical Trial Summary

In the past, a large number of animal studies have suggested that anesthesia exposure has potential neurotoxic effects, resulting in persistent cognitive and behavioral deficits. At present, there is still a lack of sufficient clinical research evidence to prove whether anesthesia exposure has long-term effects on neurodevelopment. The existing clinical research data suggests that a single short-time anesthesia exposure in young children does not affect long-term neurodevelopmental outcomes. Early onset scoliosis, including congenital scoliosis, is a type of scoliosis deformity that occurs before the age of 10. Posterior scoliosis correction surgery is one of the common treatment. There is currently no research indicating the impact of early single or multiple long-duration anesthesia exposure on the neurological development of children with congenital scoliosis. The aim of this study is to determine the long-term effect of general anesthesia exposure on neurocognitive function and behavior in children with congenital scoliosis, in order to provide reference for related clinical work.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• General Anesthetics Toxicity
• Scoliosis

• NCT number: NCT06315933
• Study type: Observational
• Source: Peking Union Medical College Hospital
• Contact: Lulu Ma, Dr.
• Phone: 0086-010-13811049619
• Email: malulu@pumch.cn
• Status: Recruiting
• Start date: January 13, 2020
• Completion date: December 2026