Gastrointestinal Hemorrhage Clinical Trial
Official title:
Endoscopic Evaluation of the Incidence and Etiology of Lower Gastrointestinal Bleeding in Patients Presenting With Melena
To evaluate the incidence and etiology of small bowel or large bowel bleeding in patients presenting with melena.
Although tarry stool is a common feature of peptic ulcer bleeding, it can also be a
manifestation of lower gastrointestinal (GI) bleeding. Examples include colonic cancer,
small bowel tumors, and small or large bowel ulcers induced by aspirin or painkillers
(NSAIDs). However, clinicians are often misled by the finding of peptic ulcers as the source
of GI bleeding. It is not uncommon to detect peptic ulcers incidentally but the source of
bleeding is actually in the lower GI tract (e.g. NSAID- or aspirin-induced small or large
bowel bleeding ulcers, small bowel tumors, or colorectal cancer). Delay in diagnosis of
lower GI bleeding often leads to serious consequences.
The preferred investigations for lower GI bleeding are colonoscopy plus video capsule
endoscopy. Colonoscopy has been the gold standard for the diagnosis of colonic bleeding. The
risk of colonoscopy-induced complications such as bleeding or perforation is less than 1 in
3500. Video capsule endoscopy is a non-invasive, safe and accurate technology that has been
approved by the FDA for investigation of small bowel diseases. The video capsule is an 11x
26mm capsule that encases a digital camera, light-emitting diodes, batteries, and a
transmitter. The patient needs to swallow the video capsule after an overnight fast and wear
a recording device for eight hours. Images are taken twice-per-second and transmitted to the
recording device. Oral feeding can be resumed after four hours. There is no restriction to
daily activities. The swallowed capsule will be expelled naturally after 5 to 12 hours
virtually in all patients. The risk of capsule retention is very low and only occurs in
patients with severe small bowel stricture.
This study aims to assess the incidence and etiology of lower GI bleeding in patients
presenting with tarry stool. The result will provide important information about the
magnitude of the problem of lower GI bleeding that will improve our patient care.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02903017 -
Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage
|
Phase 4 | |
Recruiting |
NCT02514304 -
Study of the Risk Factors and Outcomes After Gastrointestinal Bleeding
|
||
Completed |
NCT02384122 -
Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anemia Due to Angiodysplasias
|
Phase 3 | |
Completed |
NCT01477320 -
Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.
|
N/A | |
Not yet recruiting |
NCT01549418 -
The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin
|
Phase 4 | |
Completed |
NCT02105532 -
Transfusion in Gastrointestinal Bleeding
|
Phase 2/Phase 3 | |
Recruiting |
NCT05226221 -
Gastrointestinal Emergency Surgery: Evaluation of Morbidity and Mortality
|
||
Active, not recruiting |
NCT02874326 -
Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber
|
Phase 2 | |
Completed |
NCT02928939 -
Therapeutic Conflicts and Multimorbidity
|
||
Withdrawn |
NCT01215058 -
Gastroprotective Agent Compliance in Patients at Risk Suffering From a Gastrointestinal(GI) Ulcer
|
N/A | |
Completed |
NCT01029626 -
Glasgow-Blatschford Score Validation in Digestive Hemorrhage
|
N/A | |
Completed |
NCT00251979 -
A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer
|
Phase 3 | |
Completed |
NCT02991612 -
Rifaximin in Patients With Gastroesophageal Variceal Bleeding
|
N/A | |
Recruiting |
NCT02964195 -
Efficacy of Rifaximin in Treatment of Cirrhotic Gastroesophageal Variceal Bleeding
|
N/A | |
Completed |
NCT02965209 -
European Novel Motorized Spiral Endoscopy Trial
|
N/A | |
Terminated |
NCT02609100 -
Video Capsule Endoscopy Versus Colonoscopy in Patients With Melena and Negative Upper Endoscopy
|
N/A | |
Completed |
NCT02349490 -
Seraseal for Endoscopic Hemostasis
|
Phase 4 | |
Completed |
NCT01872286 -
Comparison of the Frequency-altering AKE-1 Capsule and Pillcam SB2
|
N/A | |
Withdrawn |
NCT01005147 -
Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding
|
N/A | |
Completed |
NCT00570973 -
Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy
|
Phase 4 |