High Altitude Area- A Risk Factor For Gastric Perforation?

Gastric Perforation Clinical Trial

Official title:

High Altitude Area- A Risk Factor For Gastric Perforation?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03724513
• Other study ID #: 403HAAPPU
• Status: Completed
• Start date: September 15, 2018
• Est. completion date: October 10, 2018

Study information

• Verified date: October 2018
• Source: 403 Military Field Hospital, India
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017- Aug 2018) , of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest.

Description:

INTRODUCTION : This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017- Aug 2018) , of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest.

DISCUSSION : High altitude associated dyspepsia is a common phenomenon and some studies done in high altitude population have recorded high incidence of antral gastritis and mucosal atrophy on histo-pathological evaluation. This is also supported by high incidence of H.pylori infection. The presence of atrophic gastric mucosa associated with antral gastritis, when exposed to hypobaric hypoxemic conditions faced by soldiers posted to heights above 15000ft , may leads to increased intra-luminal pressure and ischemia which probably predisposes individuals for gastric antrum perforations.

CONCLUSION : This is a relatively untouched topic as we have not found studies on high altitude related gastric perforations and probably this is the first case series of its kind. The acknowledgement of this phenomenon may pave way for further studies for defining the role of high altitude in gastric perforations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 5
• Est. completion date: October 10, 2018
• Est. primary completion date: September 30, 2018
• Accepts healthy volunteers: No
• Gender: Male
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Individuals located in High Altitude Area (>10,000ft).

• presented as perforation peritonitis.

• intra-operatively found to be perforated peptic ulcers.

Exclusion Criteria:

• Not located in High Altitude Area.

• intra-operatively perfoarations sites other then stomach and duodenum.

Related Conditions & MeSH terms

• Gastric Perforation

Locations

Country	Name	City	State
India	403 Military Field Hospital	Leh	Jammu AND Kashmir

Sponsors (1)

Lead Sponsor	Collaborator
ADITYA PAWAR

Country where clinical trial is conducted

India, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment of site of perforated peptic ulcers by intra-operative observation in cases evacuated from High Altitude Area.	Study aims at recording the site of perforated peptic ulcers in cases being evacuated in individuals posted at High Altitude Area.	1 year