Surgery Clinical Trial
Official title:
Induction Chemotherapy, Chemo-radiotherapy and Surgery in Locally Advanced Gastric Cancer Patients: Long Term Results From a Single Institution.
The aim of this study is to evaluate the efficacy of a neoadjuvant approach in patients with locally advanced gastric cancer and the identification of prognostic factors.
Patients with locally advanced gastric cancer (T3-4 and/or N+) are included. Initially,
patients are diagnosed by computerized tomography scan and endoscopic ultrasound.
The neoadjuvant strategy consists of 3-4 cycles of induction chemotherapy followed by
concurrent chemoradiotherapy. Chemoradiotherapy comprises weekly chemotherapy concurrently
with daily external beam radiotherapy up to 45 Gy). Surgery is scheduled 4 to 6 weeks after
the end of CRT. Pathological response is graded according to the Becker criteria.
Statistical analysis is performed IBM SPSS v20.
Estimate whether R0 resection rate, pathological response degree, patterns of recurrence and
long-term outcomes may be initially predicted by dynamic prognostic factors as tumor size,
neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR)
;
Observational Model: Cohort, Time Perspective: Retrospective
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