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NCT04842188 Clinical Trial

Furcation Treatment With L-PRF and aPDT

Furcation Defects Clinical Trial

Official title:
Evaluation of Leukocyte Platelet Rich Fibrin With Antimicrobial Photodynamic Therapy in Treatment of Furcation Involvement: Randomised Clinical Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04842188
Other study ID # elamrousy2020
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 28, 2020
Est. completion date April 30, 2021

Study information
Verified date June 2021
Source Kafrelsheikh University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To treat grade II periodontally diseased furcation areas Leukocyte-Platelet Rich Fibrin (L-PRF) combined with antimicrobial Photo-Dynamic Therapy (a-PDT) was used.

Description:

randomized, triple-blinded study (patient, clinician and biostatistician). Twenty-four patients with Grade II furcation involvement were recruited in this study. Control group only received L-PRF, while study group used a combination of L-PRF and aPDT Attachment level, pocket depth, horizontal component and gingival recession, also radiographic Bone depth, width, height and volume were were recorded at baseline and postoperatively after 6 months

Recruitment information / eligibility
Status Completed
Enrollment 24
Est. completion date April 30, 2021
Est. primary completion date April 12, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 32 Years to 48 Years
Eligibility Inclusion Criteria: - Grade II furcation involvement - age range 18- 50 years - 3 mm or more vertical probing depth Exclusion Criteria: - systemic disease - abnormal clotting and bleeding - smokers, - root caries or restoration - Grade II mobility - periapical lesions

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• L-PRF with aPDT
surgical open flap debridement followed by L-PRF with aPDT
• L-PRF
surgical open flap debridement followed by L-PRF alone

Locations
Country Name City State
Egypt faculty of dentistry, kafrelsheikh University Kafr Ash Shaykh

Sponsors (1)
Lead Sponsor Collaborator
Kafrelsheikh University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Clinical evaluation of Vertical clinical attachment level VCAL using periodontal probe in mm 6 months
Primary clinical evaluation of vertical pocket depth VPD using periodontal probe in mm 6 months
Primary clinical evaluation of furcation horizontal component FHC using periodontal probe in mm 6 months
Primary clinical evaluation of gingival recession REC using periodontal probe in mm 6 months
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04851548 - Evaluate the Effect of Hyaluronic Acid in the Treatment of Furcation Involvement N/A
Completed NCT03207698 - PRF+1% MF for Class II Mandibular Furcation Defects Phase 2/Phase 3
Recruiting NCT06025955 - Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement. N/A
Not yet recruiting NCT05721313 - Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study N/A
Not yet recruiting NCT05481580 - Restorations and Furcation Involvement on Molars
Recruiting NCT06060340 - Clinical and Radiographic Outcomes of Class II Furcation Defects Management Using Propolis: A Case Series Early Phase 1
Recruiting NCT05541614 - Flapless Application of Enamel Matrix Derivative in Class II Mandibular Furcation Defects N/A
Terminated NCT04059458 - Mandibular Furcation III Regeneration (FURC-III-REGEN) Phase 4
Withdrawn NCT04017429 - Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade III Furcation Defects (FURC-III-OST) N/A
Terminated NCT04059445 - Mandibular Furcation II Regeneration Phase 4
Withdrawn NCT03917030 - Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade II Furcation Defects N/A
Completed NCT02369250 - Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects Phase 4
Not yet recruiting NCT06116487 - MRI as Alternative to CBCT for the Assessment of Furcation Involvement in Molars
Completed NCT03578744 - Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects N/A
Recruiting NCT03180658 - Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans N/A
Active, not recruiting NCT05259982 - Vital Root-resective Therapy in Furcation-involved Maxillary Molars N/A
Active, not recruiting NCT02132806 - Piezosurgery in the Treatment of Class II Furcation Involvement N/A
Completed NCT02102360 - Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial. Phase 4
Not yet recruiting NCT06270303 - Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects N/A
Completed NCT03354182 - Surgical Treatment of Mandibular Furcations Using a Xenograft With/Without a Collagen Membrane N/A